Role of 20-HETE in elevating loop chloride reabsorption in Dahl SS/Jr rats

Hypertension
A P ZouR J Roman

Abstract

In vivo tubular perfusion experiments were performed in normotensive Dahl salt-sensitive (SS/Jr) and salt-resistant (SR/Jr) rats maintained from birth on a low salt (0.4% NaCl) diet to examine the role of 20-HETE in elevating loop Cl- transport in SS/Jr rats. Chloride reabsorption in the loop of Henle was significantly greater in SS/Jr than in SR/Jr rats (77 +/- 2% versus 57 +/- 3% of the perfused Cl- load). When the renal metabolism of arachidonic acid by P450 was blocked by the addition of 17-octadecynoic acid (10 micromol/L) to the perfusate, loop Cl- transport increased in SR/Jr rats to 70 +/- 2% of the delivered Cl- load, but it had no effect in SS/Jr rats. Conversely, addition of 20-HETE (10 micromol/L) to the perfusate lowered loop Cl- transport in S rats to 60 +/- 2% of perfused Cl- load, but it had no effect in SR/Jr rats. Addition of another endogenously formed HETE to the perfusate, 15-HETE (20 micromol/L), had no effect on Cl- reabsorption in the loop of Henle of SS/Jr rats. These findings indicate that endogenously produced P450 metabolites of arachidonic acid regulate Cl- transport in the loop of Henle of the rat in vivo and support the view that a diminished production of 20-HETE in the outer medulla of SS/Jr rat...Continue Reading

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Citations

Sep 24, 1999·European Journal of Pharmacology·I Messer-LétienneD Benzoni
Nov 27, 1999·Molecular Aspects of Medicine·J A Hasler
Nov 27, 2008·The Journal of Biological Chemistry·Marcela HerreraJeffrey L Garvin
Oct 12, 2010·Journal of Cardiovascular Pharmacology·Jan M WilliamsRichard J Roman
Jul 23, 1998·Clinical and Experimental Pharmacology & Physiology·I Messer-LétienneJ Sassard
Jan 15, 2013·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Joan P GravesDarryl C Zeldin
Mar 18, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Alexandra SporkováLudek Cervenka
Mar 24, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jan M WilliamsRichard J Roman
Sep 9, 2011·American Journal of Physiology. Renal Physiology·Gustavo R AresPablo A Ortiz
Feb 11, 2011·American Journal of Physiology. Renal Physiology·Mohammed Ziaul HaquePablo Alfredo Ortiz
Jul 3, 2009·American Journal of Physiology. Renal Physiology·Nader G AbrahamGeorge Drummond
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