Role of 4-hydroxynonenal in chemopreventive activities of sulforaphane.

Free Radical Biology & Medicine
Rajendra SharmaYogesh C Awasthi

Abstract

Chemoprevention of cancer via herbal and dietary supplements is a logical approach to combating cancer and currently it is an attractive area of research investigation. Over the years, isothiocyanates, such as sulforaphane (SFN) found in cruciferous vegetables, have been advocated as chemopreventive agents, and their efficacy has been demonstrated in cell lines and animal models. In vivo studies with SFN suggest that in addition to protecting normal healthy cells from environmental carcinogens, it also exhibits cytotoxicity and apoptotic effects against various cancer cell types. Among several mechanisms for the chemopreventive activity of SFN against chemical carcinogenesis, its effect on drug-metabolizing enzymes that cause activation/neutralization of carcinogenic metabolites is well established. Recent studies suggest that SFN exerts its selective cytotoxicity to cancer cells via reactive oxygen species-mediated generation of lipid peroxidation products, particularly 4-hydroxynonenal (HNE). Against the background of the known biochemical effects of SFN on normal and cancer cells, in this article we review the underlying molecular mechanisms responsible for the overall chemopreventive effects of SFN, focusing on the role of ...Continue Reading

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Citations

Oct 18, 2015·Toxicology and Applied Pharmacology·Sharad S SinghalSanjay Awasthi
Jul 8, 2014·Oxidative Medicine and Cellular Longevity·Antonio AyalaSandro Argüelles
Nov 5, 2016·Free Radical Biology & Medicine·Yogesh C AwasthiSanjay Awasthi
Jan 31, 2017·Free Radical Biology & Medicine·Ana Cipak GasparovicNeven Zarkovic
Dec 3, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Arif HussainChhavi Sharma
Jan 6, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Yao-Ping LiJin-Ming Xue
Nov 20, 2016·Journal of Neuroscience Research·Manuela PennisiVittorio Calabrese
Oct 19, 2016·Journal of Neuroscience Research·V CalabreseE J Calabrese
Aug 28, 2018·Chemical Reviews·Saba ParvezYimon Aye

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