Role of 5-HT1A receptors in the control of food intake in obese Zucker rats of different ages

Pharmacology, Biochemistry, and Behavior
J-P VoigtH Hörtnagl

Abstract

The present study describes the role of 5-HT1A receptors in the serotonergic control of food intake in obese Zucker rats of different ages. In addition, serotonin (5-HT) and cholecystokinin (CCK) content and 5-HT turnover were determined in various brain regions. The 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT; 100 microg/kg) stimulated food intake in 3-month-old lean control rats but inhibited feeding in obese Zucker rats (300 microg/kg). This pattern remained the same in 6-month-old rats. At 10 months of age, 8-OH-DPAT lost its inhibitory activity in the obese rats but still stimulated feeding in lean controls (300 microg/kg). 5-HT levels were higher in the hypothalamus and in the frontal and parietal cortices of 3-month-old obese Zucker rats and were associated with a lower cortical turnover. In the parietal cortex and the hypothalamus of 6-month-old rats, 5-HT levels were still higher, linked with a lower hypothalamic turnover. No differences were observed in 10-month-old rats. CCK content was not different between obese Zucker rats and lean rats. The persistently different feeding responses to 8-OH-DPAT in obese Zucker rats and lean controls may be related to changes in brain 5-HT metabolism i...Continue Reading

References

May 1, 1978·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·R J MartinJ H Gahagan
Jul 1, 1992·Pharmacology, Biochemistry, and Behavior·B PoeschlaG P Smith
Aug 10, 1990·European Journal of Pharmacology·P J Fletcher, M Davies
Jan 1, 1986·Physiology & Behavior·M OroscoC Jacquot
Feb 9, 1988·European Journal of Pharmacology·C S AulakhD L Murphy
Jun 10, 1988·European Journal of Pharmacology·P H HutsonG Curzon
Nov 1, 1982·Pharmacology, Biochemistry, and Behavior·J A FinkelsteinJ E Fischer
Feb 1, 1984·Neuropharmacology·M OroscoY Cohen
Oct 1, 1980·Physiology & Behavior·C L McLaughlin, C A Baile
Feb 1, 1980·Pharmacology, Biochemistry, and Behavior·J A GrinkerH Kissileff
Mar 1, 1995·Naunyn-Schmiedeberg's Archives of Pharmacology·J P VoigtC A Marsden
Feb 1, 1995·Pharmacology, Biochemistry, and Behavior·F ChaouloffV Baudrie
Feb 15, 1994·European Journal of Pharmacology·O C Meijer, E R de Kloet
Sep 1, 1995·Physiology & Behavior·V H RouthB A Horwitz
Jun 18, 1997·Regulatory Peptides·C NiederauL Herberg
Aug 11, 1998·European Journal of Pharmacology·O C MeijerE R de Kloet
Nov 7, 1998·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·S LemierreM Orosco
Nov 10, 1998·Biological Psychiatry·S F Leibowitz, J T Alexander
Jan 19, 2000·Pharmacology, Biochemistry, and Behavior·J P VoigtH Fink

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Citations

Sep 16, 2003·Regulatory Peptides·Si Ho ChoiJeong Won Jahng
Jul 30, 2005·Diabetes, Obesity & Metabolism·A J GoudieJ C G Halford
Feb 24, 2007·Progress in Neurobiology·Christian P MüllerMaria A De Souza Silva
Nov 18, 2008·Journal of Animal Physiology and Animal Nutrition·A Saadoun, M C Cabrera
May 29, 2014·British Journal of Pharmacology·M A van GestelS K Janhunen
May 3, 2005·European Journal of Pharmacology·Raquel Ferrer-LorenteMarià Alemany
Feb 2, 2011·Pharmacology, Biochemistry, and Behavior·Chandra Suma Johnson MiryalaLynda Uphouse
Sep 15, 2014·Behavioural Brain Research·Jörg-Peter Voigt, Heidrun Fink
Nov 24, 2011·Experimental Neurobiology·Young Wha MoonJeong Won Jahng
Jan 24, 2021·General and Comparative Endocrinology·Mauro ChiviteJesús M Míguez

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