PMID: 8584618Oct 1, 1995Paper

Role of 5-HT2A and 5-HT2C receptors in the stimulus effects of hallucinogenic drugs. II: Reassessment of LSD false positives

Psychopharmacology
D FiorellaJ C Winter

Abstract

In the context of animal studies of hallucinogens, an LSD-false positive is defined as a drug known to be devoid of hallucinogenic activity in humans but which nonetheless fully mimics LSD in animals. Quipazine, MK-212, lisuride, and yohimbine have all been reported to be LSD false positives. The present study was designed to determine whether these compounds also substitute for the stimulus effects of the more pharmacologically selective hallucinogen (-)DOM (0.56 mg/kg, 75-min pretreatment time). The LSD and (-)DOM stimuli fully generalized to quipazine (3.0 mg/kg) and lisuride (0.2 mg/kg), but only partially generalized to MK-212 (0.1-1.0 mg/kg) and yohimbine (2-20 mg/kg). In combination tests, pirenpirone (0.08 mg/kg), a compound with both D2 and 5-HT2A affinity, blocked the substitution of quipazine and lisuride for the (-)DOM stimulus. Ketanserin (2.5 mg/kg), an antagonist with greater than 1 order of magnitude higher affinity for 5-HT2A receptors than either 5-HT2C or D2 receptors, also fully blocked the substitution of these compounds for the (-)DOM stimulus, while the selective D2 antagonist thiothixene (0.1-1.0 mg/kg) failed to block the substitution of lisuride for the (-)DOM stimulus. These results suggest that quipa...Continue Reading

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Citations

Oct 31, 2002·Human Psychopharmacology·Sean P BarrettRobert O Pihl
Jan 13, 2005·Psychopharmacology·Michael A BenneyworthElaine Sanders-Bush
Jul 19, 2005·Psychopharmacology·C J ReissigJ C Winter
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Mar 17, 2004·Neuroscience and Biobehavioral Reviews·James B AppelJames Buggy
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Mar 20, 2002·Pharmacology, Biochemistry, and Behavior·Richard A RabinJ C Winter
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