Role of 5-HT3 receptor on food intake in fed and fasted mice

PloS One
Bingjin LiRanji Cui

Abstract

Many studies have shown that 5-hydroxytryptamine (5-HT) receptor subtypes are involved in the regulation of feeding behavior. However, the relative contribution of 5-HT3 receptor remains unclear. The present study was aimed to investigate the role of 5-HT3 receptor in control of feeding behavior in fed and fasted mice. Food intake and expression of c-Fos, tyrosine hydroxylase (TH), proopiomelanocortin (POMC) and 5-HT in the brain were examined after acute treatment with 5-HT3 receptor agonist SR-57227 alone or in combination with 5-HT3 receptor antagonist ondansetron. Food intake was significantly inhibited within 3 h after acute treatment with SR 57227 in fasted mice but not fed mice, and this inhibition was blocked by ondansetron. Immunohistochemical study revealed that fasting-induced c-Fos expression was further enhanced by SR 57227 in the brainstem and the hypothalamus, and this enhancement was also blocked by ondansetron. Furthermore, the fasting-induced downregulation of POMC expression in the hypothalamus and the TH expression in the brain stem was blocked by SR 57227 in the fasted mice, and this effect of SR 57227 was also antagonized by ondansetron. Taken together, our findings suggest that the effect of SR 57227 on t...Continue Reading

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Citations

Nov 7, 2015·Cellular and Molecular Life Sciences : CMLS·Paige V BauerFrank A Duca
Feb 12, 2017·Journal of Biochemical and Molecular Toxicology·Tongtong GeRanji Cui
Apr 9, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rosa M LeonMatthew R Hayes
Mar 17, 2020·Journal of Cellular and Molecular Medicine·Tong Tong GeBing Jin Li
Jul 28, 2016·PloS One·Sonja BialowasLennart Svensson
Jul 28, 2018·Frontiers in Physiology·Edward S Bliss, Eliza Whiteside

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

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