Role of 5-hydroxytryptamine and mast cells in the tachykinin-induced contraction of rat trachea in vitro

European Journal of Pharmacology
G F JoosR A Pauwels

Abstract

The in vivo bronchoconstrictor effect of tachykinins in Fisher 344 rats is accompanied by release into the airways of 5-hydroxytryptamine (5-HT). 5-HT is possibly derived from mast cells. In the present study the presumed mast cell-tachykinin interaction was studied in isolated trachea from Fisher 344 rats. Contractions induced by neurokinin A were largely reduced by the 5-HT antagonist methysergide, partially reduced by atropine, but not affected by hexamethonium or tetrodotoxin. Methysergide also inhibited the contractions induced by substance P, the tachykinin NK1 receptor agonist Ac[Arg6, Sar9, Met(O2)11]substance P-(6-11) and the mast cell depleting compound 48/80. Methysergide had no effect on contractions induced by carbachol or electrical field stimulation. Atropine significantly reduced contractions to 5-HT and completely inhibited contractions induced by electrical field stimulation. Histamine had no contractile effect. In vivo pretreatment with compound 48/80 significantly reduced the in vitro contractions to neurokinin A. Contractions to capsaicin were inhibited by methysergide and the tachykinin NK1 receptor antagonist (+/-)-RP67580 ((3alphaR,7alphaR)-(7,7-diphenyl-2-(1-imino-2-(2-methoxyp henylethyl)-perhydraisoin...Continue Reading

References

Sep 1, 1975·British Journal of Pharmacology·J B FarmerA M Woods
Nov 1, 1991·The American Review of Respiratory Disease·P J BarnesM G Belvisi
Dec 1, 1991·The American Review of Respiratory Disease·P J BarnesM G Belvisi
Jan 1, 1990·International Archives of Allergy and Applied Immunology·J A Kiernan
May 1, 1988·The American Review of Respiratory Disease·G F JoosM E van der Straeten
Mar 1, 1989·The Journal of Allergy and Clinical Immunology·G F JoosM E Van der Straeten
Jan 1, 1987·Annual Review of Physiology·J M Lundberg, A Saria
Sep 1, 1982·The Journal of Physiology·C M FewtrellJ M Stewart
Dec 1, 1982·Acta Physiologica Scandinavica·J M Lundberg, A Saria
Jan 1, 1983·Annual Review of Pharmacology and Toxicology·D LagunoffG Read
Sep 1, 1994·American Journal of Respiratory Cell and Molecular Biology·E K TamX Y Hua
Dec 12, 1994·European Journal of Pharmacology·G F JoosR A Pauwels
Feb 1, 1995·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L G HeaneyM Ennis
Feb 1, 1995·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J S Marshall, S Waserman
Oct 1, 1993·The American Review of Respiratory Disease·G F Joos, R A Pauwels

❮ Previous
Next ❯

Citations

Jul 26, 2005·Toxicology and Applied Pharmacology·Chien-He Lin, Yih-Loong Lai
Feb 13, 2001·European Journal of Pharmacology·I Greczko, T Tyrakowski
Nov 8, 2001·European Journal of Pharmacology·H Renz
Mar 10, 2001·Respiration Physiology·B J Canning, A Fischer
Sep 6, 2000·Trends in Pharmacological Sciences·P MontuschiG Ciabattoni
Apr 27, 2000·Allergy·G F JoosR A Pauwels
Jun 30, 2001·Japanese Journal of Pharmacology·Z IkawatiK Maeyama
Nov 5, 2013·Pulmonary Pharmacology & Therapeutics·Lisa L DupontGuy G Brusselle
Jan 29, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P ForsytheM Ennis
May 9, 2008·Pulmonary Pharmacology & Therapeutics·Brendan J Canning, Yangling Chou
Sep 2, 2006·Vascular Pharmacology·Brendan J Canning
Mar 20, 2004·Pediatric Pulmonology. Supplement·Harald Renz
Jun 10, 2003·Annals of the New York Academy of Sciences·Guy F JoosRomain A Pauwels
Apr 13, 2004·Journal of Applied Physiology·Li-Ling WuYih-Loong Lai
May 14, 2010·European Journal of Pharmacology·Manne KropA H Jan Danser

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.