PMID: 6408676Jan 1, 1983Paper

Role of 5-hydroxytryptamine in amphetamine effects on punished and unpunished behaviour

Psychopharmacology
C M LeoneF G Graeff

Abstract

In order to assess the contribution of serotonergic (5-HT) mechanisms in the suppressant effect of amphetamine on punished responding, dose-effect curves of amphetamine on key-pecking behaviour of pigeons maintained by food presentation and punished by electric-shock were determined before and after pretreatment with methergoline, a potent and specific 5-HT receptor blocker in the central nervous system. A multiple fixed-interval 5 min, fixed-interval 5 min schedule of reinforcement in which every response, except the reinforced one, was punished in one of the two components (mult FI5 FI5-shock) was used. Effective doses of amphetamine decreased unpunished as well as punished FI response rates. However, the decreases in punished behaviour were more evident and dose-dependent. Methergoline markedly increased FI responding in the punished FI component but only slightly increased or decreased unpunished FI response rates. The most effective dose of methergoline for increasing punished responding was 0.56 mg/kg. Pretreatment with this dose of methergoline unmasked the facilitatory effects of amphetamine on unpunished responding, but did not antagonize its suppressant effect on punished responding. Therefore, although 5-HT seems to ...Continue Reading

References

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Citations

Jan 1, 1985·Psychopharmacology·F G GraeffI G Karniol
Jan 15, 1988·Biological Psychiatry·R S KahnG Barr
Apr 1, 1994·European Journal of Pharmacology·C H ChengR J Naylor
Jan 1, 1990·Pharmacology & Therapeutics·G T Pollard, J L Howard
Jan 29, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jordan A MechanicFrank A Holloway
Jan 1, 1985·Psychopharmacology·M T SchützF G Graeff
Apr 14, 2016·Genetics Research International·Karina VillalbaJean Lud Cadet

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