PMID: 7768674Feb 1, 1995

Role of 5-hydroxytryptamine in mediating adenosine-induced airway contraction

Immunopharmacology
M G MateraF Rossi

Abstract

We have investigated the role of 5-hydroxytryptamine (5-HT) on adenosine-induced guinea-pig trachea contraction. R-N6-phenylisopropyladenosine (R-PIA), an A1 receptor subtype agonist, induced a concentration-dependent contraction of tracheal rings. The pD2 values were 7.43 +/- 0.26. A 30-min pretreatment with 1,3-dipropyl-8-amino-4-clorophenylxantine (PACPX), a selective A1 receptor antagonist, shifted to the right the R-PIA concentration effect curves. Ketanserin (1 microM), a 5-HT2 receptor antagonist, also caused a rightward shift of the R-PIA concentration-effect curves. The changes for the pD2 values comparing the controls and the tissues incubated with ketanserin were statistically significant (P < 0.05). In the same experimental conditions, neither atropine (1 microM), nor diphenydramine (1 microM), nor indomethacin (5 microM) showed any effects. The challenge of R-PIA (1 microM) with said substances induced a release of 5-HT (4.8 +/- 0.20 fmol/ml) from guinea-pig trachea in presence or in absence of epithelium; in the same experimental conditions, this effect did not occur in the controls. Our data support the hypothesis that 5-HT plays a role in adenosine-induced airway contraction.

References

Jul 23, 1997·European Journal of Pharmacology·P NieriM C Breschi
Feb 4, 2014·American Journal of Respiratory Cell and Molecular Biology·Brian D MooreEdward S Schelegle
Apr 18, 2012·Respiration; International Review of Thoracic Diseases·Brian D MooreEdward S Schelegle
May 27, 2006·Journal of Applied Physiology·Brendan J Canning
Aug 14, 2012·Pharmacological Reviews·Geoffrey BurnstockJean-Pierre Timmermans
Aug 8, 2018·The Journal of Clinical Pediatric Dentistry·Volkan CiftciMuharrem Cem Dogan

Citations

Aug 1, 1992·British Journal of Pharmacology·J R Thorne, K J Broadley
May 1, 1985·British Journal of Pharmacology·M J FinneyC G Persson
Jan 21, 1986·European Journal of Pharmacology·L E GustafssonB Cederqvist
Nov 1, 1988·The American Review of Respiratory Disease·P T PeachellG Marone
Aug 1, 1987·Naunyn-Schmiedeberg's Archives of Pharmacology·H SchwörerH Kilbinger
Aug 1, 1986·Acta Physiologica Scandinavica·O Nordström, D Delbro
Aug 1, 1987·The American Review of Respiratory Disease·R A Pauwels, M E Van der Straeten
Sep 7, 1987·Life Sciences·G GhaiM F Hopkins
Jan 1, 1984·International Archives of Allergy and Applied Immunology·P Kallós, L Kallós
Feb 1, 1983·British Journal of Clinical Pharmacology·M J CushleyS T Holgate
Jan 1, 1995·Allergy·M CazzolaF Rossi

Related Concepts

1,3-dipropyl-8-(2-amino-4-chlorophenyl)xanthine
Adenosine
Cavia
Osmosin
Serotonin
Antagonist Muscle Action
HTR7
Atropine
Contraction (Finding)
Trachea

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