Role of 677C→T polymorphism a single substitution in methylenetetrahydrofolate reductase (MTHFR) gene in North Indian infertile men

Molecular Biology Reports
Hena NaqviAbbas Ali Mahdi

Abstract

Failure or severe difficulty in conceiving a child is surprisingly common, worldwide problem. Half of these cases are due to male factors with defects in sperm (1 in 15 men) being the single most common cause. Also about 60-75 % of male infertility cases are idiopathic, since the molecular mechanisms underlying the defects remain unknown. DNA methylation is crucial for spermatogenesis and high methylenetetrahydrofolate reductase (MTHFR) activity in adult testis than other organs in mouse, signifies its critical role in spermatogenesis. According to recent findings there is a correlation of epigenetic regulation of several imprinted genes with disturbed spermatogenesis and fertility. Consequently any change in the MTHFR gene sequence can modify the spermatogenesis including transmission of infertility to the carriers. The aim of the study is to analyze the distribution of the single nucleotide polymorphism C677T in the MTHFR gene in 637 North Indian infertile patients and 364 fertile North Indian men as controls by using PCR-RFLP technique and Chi Square test for statistical analysis. The average MTHFR 677CC, 677CT, 677TT genotype frequencies of total infertile men were 70.17, 24.17, 5.65 % in infertile men and 75.27, 21.7, 2.74...Continue Reading

References

Dec 14, 1985·British Medical Journal·M G HullK M Desai
Mar 15, 1997·Lancet·D M de Kretser
Apr 10, 1999·European Journal of Human Genetics : EJHG·B T HeijmansE P Slagboom
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·C F SkibolaG Morgan
Feb 3, 2000·Human Reproduction·A G AndersenN E Skakkebaek
Apr 17, 2001·The New England Journal of Medicine·G BezoldR U Peter
May 2, 2003·Annals of the New York Academy of Sciences·Sharon A Ross
Nov 5, 2003·Journal of Endocrinological Investigation·L StuppiaG Palka
May 26, 2004·Lancet·Cristina Joana MarquesAlberto Barros
Nov 30, 2004·Human Reproduction·Michèle HansenJennifer J Kurinczuk
Apr 6, 2005·Human Molecular Genetics·Eamonn R Maher
Oct 26, 2005·Journal of Assisted Reproduction and Genetics·Jung Hoon ParkSuman Lee
Feb 18, 2006·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·V ParacchiniE Taioli
Jul 20, 2007·Human Molecular Genetics·Hisato KobayashiTakahiro Arima
Jan 8, 2008·Molecular Human Reproduction·C J MarquesM Sousa
Dec 25, 2008·Epigenetics : Official Journal of the DNA Methylation Society·Doria Filipponi, Robert Feil
Sep 4, 2010·Obstetrics and Gynecology International·Sheroy MinocherhomjiFiruza R Parikh
Oct 12, 2010·Journal of Postgraduate Medicine·K SinghR Raman
Dec 9, 2010·Genetic Testing and Molecular Biomarkers·Marcello Machado GavaCaio Parente Barbosa

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Citations

Sep 19, 2015·Reproductive Biomedicine Online·Hossein NikzadAbasalt Hosseinzadeh Colagar
Oct 25, 2016·Clinical Oral Investigations·Hena NaqviAbbas Ali Mahdi
Sep 12, 2020·Reproductive Biology and Endocrinology : RB&E·Fereshteh AliakbariFaezeh Azizi
Aug 16, 2017·Indian Journal of Clinical Biochemistry : IJCB·Vandana Rai, Pradeep Kumar

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