Abstract
The present study was designed to investigate the effect of 7,8-dimethoxycoumarin (DMC) isolated from ethyl acetate extract of Citrus decumana peels on gastritis in rats. Isolation of 7,8-DMC from ethyl acetate extract of C. decumana peels was done by column and preparative thin layer chromatography using different solvents on polarity basis. Furthermore, effect of 7,8-DMC (50, 75, and 100 mg/kg, i.p.) in pyloric ligation-induced gastritis was studied in rats. The highest dose of 7,8-DMC showed significant decrease in the gastric volume, total acidity, ulcerative index, thiobarbituric acid reactive species levels, and myeloperoxidase activity, whereas there was an increase in the glutathione level. However, the lowest and medium doses did not produce significant results as compared to omeprazole and N-acetyl cysteine-treated groups. Compound 7,8-DMC (100 mg/kg) showed ameliorative effect on gastric inflammation and may be used as a therapeutic agent in the treatment of gastritis.
References
Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Dec 1, 1990·Journal of Pharmacological Methods·L M HillegassC Albrightson-Winslow
Jan 1, 1986·Scandinavian Journal of Gastroenterology. Supplement·C Tasman-Jones
Sep 1, 1969·Japanese Journal of Pharmacology·K TakagiR Saziki
Jan 1, 1997·Free Radical Biology & Medicine·D DasR K Banerjee
Aug 7, 1999·International Journal of Clinical & Laboratory Research·G VendemialeE Altomare
Dec 13, 2000·Phytotherapy Research : PTR·F Borrelli, A A Izzo
Jan 30, 2003·European Journal of Internal Medicine·E K. ZervouG N. Dalekos
May 1, 1959·Archives of Biochemistry and Biophysics·G L ELLMAN
Mar 19, 2004·International Journal of Biometeorology·E Sahin, S Gümüşlü
Dec 8, 2004·Current Pharmaceutical Design·Aoife Lacy, Richard O'Kennedy
Nov 30, 2005·Journal of Ethnopharmacology·Ricardo Reyes-ChilpaSonia Mesia-Vela
Oct 26, 2007·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Giuseppe GattusoCorrado Caristi
Mar 6, 2008·Annals of Tropical Medicine and Parasitology·S C LaiH H Lee
Jun 10, 2009·Peptides·Fabricia PetronilhoEmilio L Streck
Sep 19, 2009·Inflammopharmacology·Shailja SoodPritam Dev Sharma
Dec 3, 2009·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Shailja Sood, Arunachalam Muthuraman
Jul 1, 2008·Indian Journal of Pharmaceutical Sciences· Meera, S B Kalidhar
Citations
Apr 25, 2012·Naunyn-Schmiedeberg's Archives of Pharmacology·Arunachalam MuthuramanAjay Rana
Dec 26, 2015·Chemistry Central Journal·Xinmiao LvYuanyan Liu
Apr 10, 2013·Journal of Ethnopharmacology·L N MisraFrancois Tchoumbougnang
Jun 30, 2018·Journal of Ethnobiology and Ethnomedicine·S EsakkimuthuN A Al-Dhabi