Role of a common variant of Fat Mass and Obesity associated (FTO) gene in obesity and coronary artery disease in subjects from Punjab, Pakistan: a case control study

Lipids in Health and Disease
Saleem Ullah ShahidShahida Hasnain

Abstract

The FTO gene has recently become one of the most extensively investigated genes associated with body mass and has been shown to play a role in cardiovascular diseases as well. The aim of the current study was to investigate the effect of a common variant of FTO gene, rs9939609 in obese and coronary heart disease (CHD) patients of Pakistan and investigate whether it has any influence on the serum biochemical parameters. A total of 970 samples (295 obese, 425 CHD and 250 controls) were genotyped using TaqMan allelic discrimination assay. Serum total cholesterol, HDL-C and triglycerides were measured using spectrophotometric methods. LDL-C was calculated by Friedwalds equation. Statistical analysis was done by SPSS version 22. Results showed moderately high minor allele frequency (MAF) in obese and CHD cases as compared to controls (obese = 0.381 CAD = 0.361 and controls = 0.286). The variant was significantly associated with obesity and CAD (obesity odds ratio (OR) = 1.54, confidence interval (CI) = 1.07-2.21, p = 0.0009; CHD OR = 1.43, CI = 1.02-2.01, p = 0.004) in Pakistan. The risk allele did not show a significant association with any of the lipid trait tested (p > 0.05) but a strong association was observed with plasma gluco...Continue Reading

References

Feb 11, 2005·Nature Reviews. Genetics·Christopher G BellPhilippe Froguel
Jan 18, 2007·JAMA : the Journal of the American Medical Association·Prashant JoshiSalim Yusuf
Dec 7, 2007·Molecular Genetics and Metabolism·Armand PeetersWim Van Hul
Dec 7, 2007·Journal of Molecular Evolution·Steven RobbensYves Van de Peer
Apr 1, 2008·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·R J F Loos, C Bouchard
Apr 2, 2008·Journal of Human Genetics·Kikuko HottaYusuke Nakamura
Mar 7, 2009·BMC Medical Genetics·Branwen J HennigAndrew M Prentice
Nov 17, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Meian HeLu Qi
Feb 4, 2010·European Child & Adolescent Psychiatry·Anke HinneyJohannes Hebebrand
Apr 7, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jaroslav A HubacekJan Pitha
Apr 20, 2010·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·T LappalainenUNKNOWN Finnish Diabetes Prevention Study Group
Jun 24, 2010·Circulation. Cardiovascular Genetics·Danish SaleheenPanos Deloukas
Dec 24, 2010·Diabetes Technology & Therapeutics·Kandaswamy RamyaViswanathan Mohan
Jan 6, 2011·Molecular Nutrition & Food Research·Cristina RazquinJose Alfredo Martinez
May 6, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·R DorajooE-S Tai
Jun 10, 2011·BMC Medicine·Sihua PengMaode Lai
Nov 8, 2011·Journal of Nutrigenetics and Nutrigenomics·Felix R Day, Ruth J F Loos
Jul 26, 2012·Genetic Epidemiology·Carlo BerzuiniLuisa Bernardinelli
Sep 24, 2015·European Journal of Human Genetics : EJHG· ShabanaStephen E Humphries

❮ Previous
Next ❯

Citations

Feb 16, 2019·Archives of Physiology and Biochemistry·Ehab M M AliAhmad Settin
Aug 31, 2019·Eating and Weight Disorders : EWD·Sobia Rana, Adil Anwar Bhatti
Dec 3, 2016·Biochemical Society Transactions·Veronica DeziMatthias Soller
May 16, 2021·Journal of Molecular and Cellular Cardiology·Walid Khalid SweaadUNKNOWN EU-CardioRNA COST Action CA17129
Jul 6, 2021·Oxidative Medicine and Cellular Longevity·Jun ChenDing-Sheng Jiang

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Software Mentioned

Statistical Package for Social Sciences ( SPSS
SDS )

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.