Abstract
We studied whether a hydrostatic pressure gradient between arterial blood and brain tissue plays a role in the formation of early ischemic cerebral edema after middle cerebral artery (MCA) occlusion in cats. Tissue pressure, regional CBF, and water content were measured from the cortex in the core and the peripheral zone of brain normally perfused by the MCA. Intraluminal arterial pressure was altered at intervals by inflation of an aortic balloon to vary the blood-tissue pressure gradient in the ischemic zone. Brain water content in the ischemic core, where flow fell to 5.5 ml/100 g/min, increased within 1 h of occlusion. After occlusion tissue pressure rose from 7.95 +/- 0.72 mm Hg at 1 h to 13.16 +/- 1.13 mm Hg at 3 h. When intraluminal pressure was increased, water content increased further, but only at 1 h after occlusion. In the periphery where flow was 18.9 ml/100 g/min during normotension, neither water content nor tissue pressure rose within 3 h of occlusion. Increased intraluminal pressure was accompanied by increased water content only at 3 h. This study indicates that a hydrostatic pressure gradient is an important element in the development of ischemic brain edema, exerting its major effect during the initial phase...Continue Reading
References
Feb 1, 1986·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S Hatashita, J T Hoff
Apr 1, 1986·Journal of Neurosurgery·S HatashitaS Ishii
Jan 1, 1985·Journal of Neurosurgery·B A BellN M Branston
Jan 1, 1985·Journal of Neurosurgery·F IannottiG P Schielke
Jul 1, 1985·Stroke; a Journal of Cerebral Circulation·S HatashitaS Ishii
Jul 1, 1973·Stroke; a Journal of Cerebral Circulation·E PasztorN M Branston
Jan 1, 1967·Journal of Neuropathology and Experimental Neurology·I Klatzo
Feb 1, 1971·Journal of Applied Physiology·S R NelsonJ A Maxwell
Sep 1, 1983·Stroke; a Journal of Cerebral Circulation·T ShimaH Date
Jun 1, 1984·Journal of Neurosurgery·F IannottiG P Schielke
Nov 1, 1980·Stroke; a Journal of Cerebral Circulation·F J Schuier, K A Hossmann
Mar 1, 1981·Annals of Neurology·K KogureP Scheinberg
Citations
Jan 1, 1991·Acta Neuropathologica·P M PatelJ Steinauer
Jan 1, 1991·Acta Neuropathologica·D J ColeM H Wong
Jan 1, 1991·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·Z KotwicaL Persson
Dec 31, 2002·Surgical Neurology·Anthony L D'AmbrosioE Sander Connolly
Oct 21, 2000·Journal of Neuroscience Methods·S TakahashiS Yoshida
Dec 3, 2010·Journal of Neurotrauma·Rick M OdlandGaylan L Rockswold
Mar 1, 1994·Pathology International·T Kuroiwa, R Okeda
Aug 10, 2011·Neurosurgery·Rick M OdlandScott Panter
Aug 11, 2007·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Naohisa HosomiMasakazu Kohno
Apr 2, 2002·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Cenk Ayata, Allan H Ropper
Dec 10, 1987·The New England Journal of Medicine·J C Grotta
Oct 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S YamaguchiM Kitani
Jan 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D J ColeR M Schell
Aug 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S HatashitaS M Salamat
Jan 1, 1988·Stroke; a Journal of Cerebral Circulation·S Hatashita, J T Hoff
Sep 1, 1990·Stroke; a Journal of Cerebral Circulation·D J ColeN H Peckham
Apr 1, 1990·Stroke; a Journal of Cerebral Circulation·S Hatashita, J T Hoff
Sep 20, 2002·Journal of Radiation Research·Sentaro TakahashiKumie Nojima