Role of A1 adenosine receptor in the regulation of coronary flow

American Journal of Physiology. Heart and Circulatory Physiology
Huda E TawfikS J Mustafa

Abstract

To determine whether A1 adenosine receptors (AR) participate in adenosine-induced changes of coronary flow, isolated hearts from A1AR(-/-) and A1AR(+/+) mice were perfused under constant pressure, and the effects of nonselective and selective agonists were examined. Adenosine, 5'-N-ethylcarboxamidoadenosine (NECA, nonselective), and the selective A2AAR agonist 2-2-carboxyethylphenethylamino-5'-N-ethylcarboxamidoadenosine (CGS-21680) augmented maximal coronary vasodilation in A1AR(-/-) hearts compared with A1AR(+/+) hearts. Basal coronary flow was increased (P < 0.05) in A1AR(-/-) hearts compared with A1AR(+/+) hearts: 2.548 +/- 0.1 vs. 2.059 +/- 0.17 ml/min. In addition, selective activation of A1AR with 2-chloro-N6-cyclopentyladenosine (CCPA) at nanomolar concentrations (1-100 nM) did not significantly change coronary flow; at higher concentrations, CCPA increased coronary flow in A1AR(-/-) and A1AR(+/+) hearts. Because deletion of A1AR increased basal coronary flow, it is speculated that this effect is due to removal of an inhibitory influence associated with A1AR. Adenosine and NECA at approximately EC50 (100 and 50 nM, respectively) increased coronary flow in A1AR(+/+) hearts to 177.86 +/- 8.75 and 172.72 +/- 17% of baselin...Continue Reading

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Citations

Sep 3, 2013·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Zhichao ZhouDaphne Merkus
Jan 5, 2013·Journal of Cardiovascular Pharmacology·Bunyen TengS Jamal Mustafa
Sep 22, 2010·The Journal of Pharmacology and Experimental Therapeutics·Xin LongMichael Sturek
Sep 29, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Maryam Sharifi SanjaniS Jamal Mustafa
Sep 15, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Dovenia S PonnothS Jamal Mustafa
Jul 14, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Habib R AnsariS Jamal Mustafa
Dec 26, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mohammed A NayeemS Jamal Mustafa
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May 9, 2006·American Journal of Physiology. Heart and Circulatory Physiology·R Ray MorrisonS Jamal Mustafa
Sep 18, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Xueping ZhouS Jamal Mustafa
Oct 9, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Habib R AnsariS Jamal Mustafa
Mar 13, 2021·Circulation. Cardiovascular Imaging·Soham A ShahFrederick H Epstein
Mar 24, 2021·Basic Research in Cardiology·Ying ZhangZhichao Zhou

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