PMID: 11901931Mar 21, 2002Paper

Role of acid and bile in the genesis of Barrett's esophagus

Chest Surgery Clinics of North America
Werner K H Kauer, Hubert J Stein

Abstract

Clinical and experimental studies have shown that acid and bile reflux are increased in patients who have Barrett's esophagus. The combination of both seems the key factor in the pathogenesis of Barrett's esophagus. This factor has been confirmed by immunohistochemical studies that show that environmental factors, such as acid and bile, are involved in the pathogenesis of Barrett's esophagus. There is a critical pH range between 3 and 6 in which bile acids exist in their soluble, un-ionized form; can penetrate cell membranes; and accumulate within mucosal cells. At a lower pH, bile acids are precipitated, and at a higher pH, bile acids exist in their noninjurious ionized form. Thus incomplete gastric acid suppression, as is the case with most medical treatment regimens for gastroesophageal reflux, may in fact predispose to the development of Barrett's esophagus.

References

Oct 1, 1986·Digestive Diseases and Sciences·E J SchweitzerJ W Harmon
Jan 1, 1981·Digestive Diseases and Sciences·J W HarmonC L Maydonovitch

❮ Previous
Next ❯

Citations

Nov 28, 2012·Digestive Diseases and Sciences·I LeeuwenburghE J Kuipers
Apr 21, 2007·Pediatrics International : Official Journal of the Japan Pediatric Society·Rok Orel, Gaj Vidmar
Nov 24, 2004·The American Journal of Gastroenterology·Brenda C WesthoffPrateek Sharma
Jul 22, 2020·Journal of Cellular and Molecular Medicine·Sotirios G DoukasDimitra Vageli
Jun 8, 2019·Cancer Medicine·Sotirios G DoukasClarence T Sasaki
Apr 2, 2003·Current Oncology Reports·Burkhard H A von RahdenJörg R Siewert
Mar 18, 2021·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Alfredo GencoGiovanni Casella
Jan 1, 2021·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Alfredo GencoGiovanni Casella
Jan 18, 2005·Mutation Research·H BernsteinH Garewal
Sep 25, 2021·Oncology Reports·Dimitra P VageliBenjamin L Judson
Nov 6, 2021·The British Journal of Surgery·Alfredo GencoGiovanni Casella

❮ Previous
Next ❯

Related Concepts

Related Feeds

Barrett Esophagus

Barrett’s esophagus if a serious complication of gastroesophageal reflux disease during which the normal esophageal lining changes to tissue that resembles intestinal lining. Here is the latest research.