Role of acid-sensing ion channel 3 in sub-acute-phase inflammation.

Molecular Pain
Yi-Tin YenChih-Cheng Chen

Abstract

Inflammation-mediated hyperalgesia involves tissue acidosis and sensitization of nociceptors. Many studies have reported increased expression of acid-sensing ion channel 3 (ASIC3) in inflammation and enhanced ASIC3 channel activity with pro-inflammatory mediators. However, the role of ASIC3 in inflammation remains inconclusive because of conflicting results generated from studies of ASIC3 knockout (ASIC3-/-) or dominant-negative mutant mice, which have shown normal, decreased or increased hyperalgesia during inflammation. Here, we tested whether ASIC3 plays an important role in inflammation of subcutaneous tissue of paw and muscle in ASIC3-/- mice induced by complete Freund's adjuvant (CFA) or carrageenan by investigating behavioral and pathological responses, as well as the expression profile of ion channels. Compared with the ASIC3+/+ controls, ASIC3-/- mice showed normal thermal and mechanical hyperalgesia with acute (4-h) intraplantar CFA- or carrageenan-induced inflammation, but the hyperalgesic effects in the sub-acute phase (1-2 days) were milder in all paradigms except for thermal hyperalgesia with CFA-induced inflammation. Interestingly, carrageenan-induced primary hyperalgesia was accompanied by an ASIC3-dependent Nav...Continue Reading

References

Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·H KimJ Deisenhofer
Aug 4, 1998·Current Opinion in Neurobiology·R Waldmann, M Lazdunski
Jan 13, 2000·Clinics in Dermatology·B BianchiT M Lotti
Aug 17, 2001·European Journal of Gastroenterology & Hepatology·Y YiangouP Anand
Aug 31, 2001·Nature Neuroscience·D C Immke, E W McCleskey
Nov 20, 2001·Current Opinion in Pharmacology·P W Reeh, M Kress
Jun 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Chih-Cheng ChenAndreas Zimmer
Jun 28, 2002·Cleveland Clinic Journal of Medicine·Michael C Sneller
May 3, 2005·British Journal of Anaesthesia·T A Pham-MarcouJ-X Mazoit
Jun 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Birgit T PriestWilliam J Martin
Jul 5, 2005·Nature Reviews. Neuroscience·Fabien MarchandStephen B McMahon
Oct 28, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jeffrey S MogilPhilippe Séguéla
Nov 25, 2005·Molecular Pain·Derek C MolliverEdwin W McCleskey
Jan 16, 2007·Journal of Pharmacological Sciences·Taixing ZhengNobukuni Ogata
Apr 14, 2007·The Journal of Biological Chemistry·Eric Lingueglia
Aug 28, 2007·Molecular and Cellular Neurosciences·Chia-Wei HuangWei-Hsin Sun
Nov 30, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hervé CadiouPeter A McNaughton
Aug 2, 2008·Science·Bjarke AbrahamsenJohn N Wood
Oct 17, 2008·The EMBO Journal·Emmanuel DevalEric Lingueglia

❮ Previous
Next ❯

Citations

Jan 13, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Wei HuMei-Ying Lin
Jan 19, 2011·ACS Chemical Neuroscience·Wei-Guang Li, Tian-Le Xu
Nov 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Chia-Ching John LinChih-Cheng Chen
Jul 26, 2012·Proceedings of the National Academy of Sciences of the United States of America·Anne DelaunayEmmanuel Deval
Aug 23, 2012·Journal of Biomedical Science·Masashi IzumiToshikazu Tani
Aug 2, 2011·Biological & Pharmaceutical Bulletin·Hiroshi Ueda
Dec 4, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Ching-Feng ChengChih-Cheng Chen
Feb 10, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Cheng-Han LeeChih-Cheng Chen
Jun 21, 2014·Biologie aujourd'hui·Eric Lingueglia
Sep 18, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Li-Chai ChenZhi-Hong Wen
Jan 13, 2015·Molecular Neurobiology·Nicholas S GregoryKathleen A Sluka
Jan 12, 2012·Pharmacology & Therapeutics·Wei-Li WuChih-Cheng Chen
Sep 3, 2010·Pharmacology & Therapeutics·Emmanuel DevalEric Lingueglia
Mar 27, 2010·The Journal of Pain : Official Journal of the American Pain Society·Hyoung-Sig SeoJang-Hern Lee
Dec 18, 2009·The Journal of Pain : Official Journal of the American Pain Society·Roxanne Y WalderKathleen A Sluka
Dec 5, 2015·Journal of Molecular Neuroscience : MN·Yeu-Shiuan SuWei-Hsin Sun
Jan 22, 2013·Arthritis and Rheumatism·Kathleen A SlukaGary S Firestein
Mar 16, 2013·Journal of Cellular and Molecular Medicine·Chih-Cheng Chen, Chia-Wen Wong
Mar 1, 2015·Neuropharmacology·Emmanuel Deval, Eric Lingueglia
Jan 15, 2015·Neuropharmacology·Kathleen A Sluka, Nicholas S Gregory
Jan 15, 2015·Neuropharmacology·Shing-Hong LinChih-Cheng Chen
May 8, 2014·BioMed Research International·Ching-Feng ChengChih-Cheng Chen
Nov 26, 2015·Journal of Dental Research·W H Sun, C C Chen
May 17, 2018·Tissue Engineering. Part a·Juliane D GlaeserHyun W Bae
May 22, 2018·CNS Neuroscience & Therapeutics·Xiao-Gang YanJian-Hua Liu
Jan 19, 2018·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Liang-Ta YenYi-Wen Lin
May 1, 2010·Expert Review of Clinical Pharmacology·Jacques NoëlEric Lingueglia
Mar 22, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Chunyang MengKaizhi Li

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Software Mentioned

ImageProPlus

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Cellulitis

Cellulitis (erysipelas) is a recurring and debilitating bacterial infection of the skin and underlying tissue. Discover the latest research on cellulitis here.