Role of acid-sensing ion channels in hypoxia- and hypercapnia-induced ventilatory responses

PloS One
Neil D DetweilerNikki L Jernigan

Abstract

Previous reports indicate roles for acid-sensing ion channels (ASICs) in both peripheral and central chemoreception, but the contributions of ASICs to ventilatory drive in conscious, unrestrained animals remain largely unknown. We tested the hypotheses that ASICs contribute to hypoxic- and hypercapnic-ventilatory responses. Blood samples taken from conscious, unrestrained mice chronically instrumented with femoral artery catheters were used to assess arterial O2, CO2, and pH levels during exposure to inspired gas mixtures designed to cause isocapnic hypoxemia or hypercapnia. Whole-body plethysmography was used to monitor ventilatory parameters in conscious, unrestrained ASIC1, ASIC2, or ASIC3 knockout (-/-) and wild-type (WT) mice at baseline, during isocapnic hypoxemia and during hypercapnia. Hypercapnia increased respiratory frequency, tidal volume, and minute ventilation in all groups of mice, but there were no differences between ASIC1-/-, ASIC2-/-, or ASIC3-/- and WT. Isocapnic hypoxemia also increased respiratory frequency, tidal volume, and minute ventilation in all groups of mice. Minute ventilation in ASIC2-/- mice during isocapnic hypoxemia was significantly lower compared to WT, but there were no differences in the r...Continue Reading

References

Dec 1, 1985·Journal of Applied Physiology·B R WalkerN F Voelkel
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·J UreñaJ López-Barneo
Feb 1, 1997·The Journal of Physiology·K J Buckler
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Christopher J BensonPeter M Snyder
Jun 15, 2004·Journal of Applied Physiology·Masahiko IzumizakiIkuo Homma
Aug 8, 2006·Trends in Neurosciences·John A WemmieMichael J Welsh
Apr 20, 2007·Respiratory Physiology & Neurobiology·José Ramón López-López, M Teresa Pérez-García
Dec 21, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniel K MulkeyDouglas A Bayliss
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Christian GestreauJacques Barhanin
Mar 31, 2010·The Journal of General Physiology·Patricia Ortega-SáenzJosé López-Barneo
Aug 26, 2010·The Journal of Comparative Neurology·Patrice G GuyenetDouglas A Bayliss
Sep 6, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·X LiuS J Fidone
Nov 28, 2012·Wiley Interdisciplinary Reviews. Membrane Transport and Signaling·Zhi-Gang Xiong, Tian-Le Xu
Jun 21, 2013·Nature Reviews. Neuroscience·John A WemmieCollin J Kreple
Oct 11, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sheng WangDouglas A Bayliss
Nov 5, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Carlos H NittaNikki L Jernigan
May 23, 2014·Proceedings of the National Academy of Sciences of the United States of America·Tudor BartoiMaximilian H Ulbrich

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Citations

Oct 17, 2019·Annual Review of Physiology·Patricia Ortega-Sáenz, José López-Barneo
Jan 28, 2020·American Journal of Physiology. Renal Physiology·Marcelo D Carattino, Nicolas Montalbetti
May 7, 2020·Animals : an Open Access Journal From MDPI·Enver ÇavuşoğluDonald C Lay
Mar 5, 2021·Bio-protocol·Patricia Prada-DacasaAlbert Quintana
Mar 25, 2021·The Journal of Physiology·Stephen B G Abbott, George M P R Souza
Feb 12, 2021·Physiological Reviews·Rodrigo IturriagaVirend K Somers
Sep 6, 2020··Laura Sánchez-BenitoPatricia Prada-Dacasa

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BETA
PCR
transgenic

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GraphPad Prism

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