Role of activating FcγR gene polymorphisms in Kawasaki disease susceptibility and intravenous immunoglobulin response.

Circulation. Cardiovascular Genetics
Sadeep ShresthaMichael A Portman

Abstract

A functional polymorphism in the inhibitory IgG-Fc receptor gene FcγRIIB influences intravenous immunoglobulin (IVIG) response in Kawasaki disease (KD), a vasculitis preferentially affecting the coronary arteries in children. We tested the hypothesis that the polymorphisms in the activating receptors (FcγRIIA, FcγRIIIA, and FcγRIIIB) also influence susceptibility, IVIG treatment response, and coronary artery disease in patients with KD. We genotyped polymorphisms in the activating FcγRIIA, FcγRIIIA, and FcγRIIIB using pyrosequencing in 443 patients with KD, including 266 trios and 150 single parent-child pairs, in northwest United States and genetically determined race with 155 ancestry informative markers. We used family-based association to test for transmission disequilibrium and further generated pseudosibling controls for comparisons with the cases. The FcγRIIA-131H variant showed an association with KD (P=0.001) with an additive odds ratio (OR) of 1.51 (95% CI, 1.16-1.96; P=0.002) for the primary combined population, which persisted in both white (P=0.04) and Asian (P=0.01) subgroups and is consistent with the recent genome-wide association study. We also identified overtransmission of the FcγRIIIB neutrophil antigen 1 (N...Continue Reading

References

Nov 10, 1984·Lancet·K FurushoT Yokoyama
Jul 31, 1998·Immunogenetics·W van der Pol, J G van de Winkel
Mar 13, 2001·Annual Review of Immunology·J V Ravetch, S Bolland
Apr 22, 2003·The Journal of Allergy and Clinical Immunology·Bryce A BinstadtFrancisco A Bonilla
Aug 11, 2004·Lancet·Jane C Burns, Mary P Glodé
Dec 3, 2004·Pediatrics·Jane W NewburgerUNKNOWN Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American H
Sep 1, 2005·Journal of Clinical Immunology·Shoichiro TaniuchiYohnosuke Kobayashi
Dec 21, 2006·Clinical and Experimental Immunology·M BiezeveldT Kuijpers
Jun 20, 2007·Circulation·Brian W McCrindleUNKNOWN Pediatric Heart Network Investigators
Jan 10, 2008·Human Molecular Genetics·Jeffrey C EdbergRobert P Kimberly
Feb 10, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nihad MeknacheMarc Daëron
May 13, 2009·Proceedings of the National Academy of Sciences of the United States of America·Irma Silva-ZolezziGerardo Jimenez-Sanchez
Jul 17, 2009·Clinical and Experimental Immunology·S BournazosI Dransfield
Dec 21, 2010·The Journal of Pediatrics·Lynn A SleeperUNKNOWN Pediatric Heart Network Investigators
May 24, 2011·The Journal of Allergy and Clinical Immunology·Sadeep ShresthaMichael A Portman
Nov 15, 2011·Nature Genetics·Chiea Chuen KhorUNKNOWN Blue Mountains Eye Study

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Citations

Sep 7, 2013·Pediatric Rheumatology Online Journal·Michael A PortmanSadeep Shrestha
Feb 18, 2014·Human Immunology·Marlena J TypiakAnna Dubaniewicz
Mar 28, 2013·Computational and Mathematical Methods in Medicine·Yu-wen LvHai-tao Lv
Jan 8, 2016·International Journal of Environmental Research and Public Health·Deniz YeterHo-Chang Kuo
Feb 14, 2014·Expert Opinion on Therapeutic Targets·Xinrui Li, Robert P Kimberly
Apr 9, 2015·Pediatric Allergy, Immunology, and Pulmonology·Georgios A HartasMonesha Gupta-Malhotra
Apr 30, 2014·Cardiology in the Young·Anthoula ChatzikyriakidouLiana Fidani
Feb 6, 2015·Frontiers in Immunology·Sietse Q Nagelkerke, Taco W Kuijpers
Feb 27, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M L ArnoldG A Böhmig
Jun 21, 2012·Circulation. Cardiovascular Genetics·Jane C Burns, Jane W Newburger
Oct 14, 2017·Circulation. Cardiovascular Genetics·Michael A Portman, Sadeep Shrestha
Apr 6, 2019·Frontiers in Immunology·Sietse Q NagelkerkeUNKNOWN International Kawasaki Disease Genetics Consortium
Sep 12, 2019·Frontiers in Immunology·Yu Wang, Friederike Jönsson
Dec 11, 2019·Antibodies·Veena A Thomas, Joseph P Balthasar
Apr 8, 2020·Cardiovascular Therapeutics·Zhouping WangXiaoqiong Gu
Jun 24, 2015·Expert Review of Clinical Immunology·Jane C Burns, Alessandra Franco
Aug 26, 2017·Nutrition Reviews·Mark MessinaDan Waitzberg
Mar 19, 2019·The Pediatric Infectious Disease Journal·Akiko Sugahara-TobinaiSatoru Kumaki
Jan 23, 2020·Journal of Human Genetics·Hea-Ji KimUNKNOWN Korean Kawasaki Disease Genetics Consortium
May 28, 2020·Frontiers in Pediatrics·Alessandro GambacortaPiero Valentini
Apr 12, 2019·The Pharmacogenomics Journal·Jae-Jung KimUNKNOWN and the Korean Kawasaki Disease Genetics Consortium
Jul 22, 2019·Pediatric Rheumatology Online Journal·Wei-Dong HuangHo-Chang Kuo
Aug 21, 2019·Frontiers in Immunology·Marialbert Acosta-HerreraAna Márquez
Jun 29, 2017·European Journal of Pediatrics·S M DietzT W Kuijpers
Dec 6, 2017·International Journal of Rheumatic Diseases·Mindy S Lo, Jane W Newburger
Dec 1, 2015·Indian Journal of Rheumatology·Dhrubajyoti Sharma, Surjit Singh
Nov 26, 2020·The Journal of Pediatrics·Luz A PadillaSadeep Shrestha
Sep 28, 2020·The Journal of Pediatrics·Luz A PadillaSadeep Shrestha
May 11, 2021·Autoimmunity Reviews·Naresh RambabuJagadeesh Bayry
Jul 13, 2021·Frontiers in Pediatrics·Kaushal SharmaSurjit Singh

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