Role of activating transcription factor 3 and its interacting proteins under physiological and pathological conditions

International Journal of Biological Macromolecules
M RohiniN Selvamurugan

Abstract

Activating transcription factor 3 (ATF3) is a stress-responsive factor that belongs to the activator protein 1 (AP-1) family of transcription factors. ATF3 expression is stimulated by various factors such as hypoxia, cytokines, and chemotherapeutic and DNA damaging agents. Upon stimulation, ATF3 can form homodimers or heterodimers with other members of the AP-1 family to repress or activate transcription. Under physiological conditions, ATF3 expression is transient and plays a pivotal role in controlling the expression of cell-cycle regulators and tumor suppressor, DNA repair, and apoptosis genes. However, under pathological conditions such as those during breast cancer, a sustained and prolonged expression of ATF3 has been observed. In this review, the structure and function of ATF3, its posttranslational modifications (PTM), and its interacting proteins are discussed with a special emphasis on breast cancer metastasis.

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Citations

Dec 19, 2019·International Journal of Molecular Sciences·Pavlína ŠimečkováMiroslav Machala
Aug 21, 2020·Proceedings of the National Academy of Sciences of the United States of America·Zhe Sha, Alfred L Goldberg
Sep 15, 2020·Frontiers in Endocrinology·Hui-Chen Ku, Ching-Feng Cheng
Dec 11, 2020·Pharmacogenomics and Personalized Medicine·Chao-Yi GeHua-Hong Wang
Jul 13, 2020·Current Cancer Drug Targets·Ravishkumar L AkshayaNagarajan Selvamurugan
Apr 23, 2021·The International Journal of Biological Markers·Erika KorobeinikovaElona Juozaityte
Aug 10, 2021·F1000Research·Rafael Sebastián Fort, María Ana Duhagon

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