Role of activation of bradykinin B2 receptors in disruption of the blood-brain barrier during acute hypertension

Brain Research
W G Mayhan

Abstract

Cellular mechanisms which account for disruption the blood-brain barrier during acute hypertension are not clear. The goal of this study was to determine the role of synthesis/release of bradykinin to activate B2 receptors in disruption of the blood-brain barrier during acute hypertension. Permeability of the blood-brain barrier was quantitated by clearance of fluorescent-labeled dextran before and during phenylephrine-induced acute hypertension in rats treated with vehicle and Hoe-140 (0.1 microM). Phenylephrine infusion increased arterial pressure, arteriolar diameter and clearance of fluorescent dextran by a similar magnitude in both groups. These findings suggest that disruption of the blood-brain barrier during acute hypertension is not related to the synthesis/release of bradykinin to activate B2 receptors.

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Citations

Jan 19, 2008·Proceedings of the National Academy of Sciences of the United States of America·Laibaik ParkCostantino Iadecola
Nov 14, 2001·The Journal of Trauma·M RachinskyY Shapira
May 31, 2001·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·W G Mayhan
Dec 17, 2014·European Journal of Pharmacology·Raphael BoursereauJean-Luc Morel
Dec 29, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K NiwaC Iadecola
Feb 7, 2008·The Cochrane Database of Systematic Reviews·K Ker, K Blackhall
Apr 12, 2001·American Journal of Physiology. Heart and Circulatory Physiology·J E BrianS A Moore

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