Role of Activator Protein-1 Complex on the Phenotype of Human Osteosarcomas Generated from Mesenchymal Stem Cells

Stem Cells
Stefano GamberaJavier García-Castro

Abstract

Osteosarcoma (OS) is a highly aggressive bone tumor that usually arises intramedullary at the extremities of long bones. Due to the fact that the peak of incidence is in the growth spurt of adolescence, the specific anatomical location, and the heterogeneity of cells, it is believed that osteosarcomagenesis is a process associated with bone development. Different studies in murine models showed that the tumor-initiating cell in OS could be an uncommitted mesenchymal stem cell (MSC) developing in a specific bone microenvironment. However, only a few studies have reported transgene-induced human MSCs transformation and mostly obtained undifferentiated sarcomas. In our study, we demonstrate that activator protein 1 family members induce osteosarcomagenesis in immortalized hMSC. c-JUN or c-JUN/c-FOS overexpression act as tumorigenic factors generating OS with fibroblastic or pleomorphic osteoblastic phenotypes, respectively. Stem Cells 2018;36:1487-1500.

References

Jul 22, 1998·Virchows Archiv : an International Journal of Pathology·A FranchiG Zampi
Dec 10, 1999·Experimental Cell Research·W Wei, J M Sedivy
Jun 30, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·I SulzbacherA Chott
Jun 13, 2001·Oncogene·W JochumE F Wagner
Oct 5, 2001·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S FerrariG Bacci
Sep 19, 2002·Biochemical and Biophysical Research Communications·Valentine B AndelaRandy N Rosier
Oct 16, 2002·Annals of the Rheumatic Diseases·E F Wagner
Dec 12, 2003·Nature Reviews. Cancer·Robert Eferl, Erwin F Wagner
Apr 27, 2004·Oncogene·Nedime SerakinciMoustapha Kassem
Nov 24, 2005·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Huamin ZhouJiahuai Han
Mar 27, 2007·Proceedings of the National Academy of Sciences of the United States of America·Juan M FunesChris Boshoff
Mar 10, 2010·Cancer Treatment and Research·Richard Gorlick
May 12, 2011·Sarcoma·Matthew L BroadheadPeter F M Choong
Jun 28, 2011·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Minli LiZuhong Lu
Sep 21, 2011·Cell Research·Rene RodriguezPablo Menendez
Mar 29, 2012·Genes, Chromosomes & Cancer·Marieke L KuijjerAnne-Marie Cleton-Jansen
Apr 27, 2012·Journal of the National Cancer Institute·Qing-Lian TangTiebang Kang
Jun 12, 2012·Sarcoma·Jeff W MartinMaria Zielenska
Oct 6, 2012·Clinical Sarcoma Research·Alvin Jm NgCarl R Walkley
Feb 14, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Andrew A WilsonDarrell N Kotton
May 14, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Hiroko NishidaTaketo Yamada
May 17, 2014·Journal of Medicinal Chemistry·Na YeJia Zhou
Sep 12, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·UNKNOWN ESMO/European Sarcoma Network Working Group
Jan 22, 2015·Nucleic Acids Research·Matthew E RitchieGordon K Smyth
Mar 31, 2015·The Journal of Clinical Investigation·Jinchang LuJin Wang
May 4, 2015·Cellular and Molecular Life Sciences : CMLS·Arantzazu AlfrancaRene Rodriguez
Oct 27, 2017·Stem Cells Translational Medicine·Federica PapaccioVirginia Tirino

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Citations

Dec 19, 2019·International Journal of Molecular Sciences·M Piñeiro-RamilS M Díaz-Prado
Jul 1, 2021·Signal Transduction and Targeted Therapy·Victoria DamerellSharon Prince

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