Role of active movement in place-specific firing of hippocampal neurons

Hippocampus
Eun Young SongMin Whan Jung

Abstract

The extent of external and internal factors contributing to location-specific firing of hippocampal place cells is currently unclear. We investigated the role of active movement in location-specific firing by comparing spatial firing patterns of hippocampal neurons, while rats either ran freely or rode a motorized cart on the same circular track. Most neurons changed their spatial firing patterns across the two navigation conditions ("remapping"), and they were stably maintained across repeated active or passive navigation sessions. These results show that active movement is a critical factor in determining place-specific firing of hippocampal neurons. This could explain why passive displacement is not an effective way of acquiring spatial knowledge for subsequent active navigation in an unfamiliar environment.

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Citations

May 27, 2011·Journal of Neurophysiology·Michael E Shinder, Jeffrey S Taube
Jul 12, 2007·Dementia and Geriatric Cognitive Disorders·Pamela L Sheridan, Jeffrey M Hausdorff
Sep 6, 2007·PLoS Computational Biology·Mathias FranziusLaurenz Wiskott
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Jul 14, 2020·Brain Injury : [BI]·Ana Isabel Useros OlmoJuan Carlos Miangolarra Page
Feb 28, 2019·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yan LiuRaymond Chuen-Chung Chang
Apr 12, 2017·Proceedings of the National Academy of Sciences of the United States of America·Zoltan NadasdyRobert J Buchanan
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Jul 3, 2019·Frontiers in Cellular Neuroscience·Céline Drieu, Michaël Zugaro
Apr 20, 2018·Brain Structure & Function·Catarina Rendeiro, Justin S Rhodes
Mar 7, 2021·Proceedings of the National Academy of Sciences of the United States of America·Daniel Pacheco EstefanPaul F M J Verschure
Aug 27, 2009·Learning & Memory·Jong Won LeeMin Whan Jung
Mar 14, 2007·Learning & Memory·Sung H YunMin W Jung

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