Role of adenosine in behavioral state modulation: a microdialysis study in the freely moving cat

Neuroscience
C M PortasR W McCarley

Abstract

There is considerable evidence to suggest that the activity of forebrain and mesopontine cholinergic neurons is intimately involved in electroencephalographic arousal. Furthermore, our previous in vitro investigation suggested that both cholinergic systems are under a powerful tonic inhibitory control by endogenous adenosine. We thus examined the in vivo effect, on electrographically defined behavioral states, of microdialysis perfusion of adenosine into the cholinergic zones of the substantia innominata of the basal forebrain and the laterodorsal tegmental nucleus of freely moving cats. Localized perfusion of adenosine into either the basal forebrain or the laterodorsal tegmental nucleus caused a marked alteration in sleep-wake architecture. Adenosine (300 microM) perfused into either the basal forebrain or laterodorsal tegmental nucleus produced a dramatic decrease in waking, to about 50% of the basal level. Perfusion into the basal forebrain resulted in a significant increase in rapid eye movement sleep, while slow wave sleep was unchanged. In contrast, adenosine perfusion into the laterodorsal tegmental nucleus produced an increase of both slow wave sleep and rapid eye movement sleep, the magnitude of which were proportiona...Continue Reading

References

Nov 1, 1979·Canadian Journal of Physiology and Pharmacology·J W PhillisJ R Kirkpatrick
Jan 1, 1991·Progress in Neurobiology·R W Greene, H L Haas
Aug 1, 1990·Brain Research Bulletin·J CornwallO T Phillipson
Sep 1, 1991·Pharmacology, Biochemistry, and Behavior·S R Ticho, M Radulovacki
Feb 1, 1989·Brain Research Bulletin·R Szymusiak, D McGinty
Apr 1, 1989·Brain Research Bulletin·N Quan, C M Blatteis
Apr 2, 1986·Brain Research·R Szymusiak, D McGinty
Dec 1, 1972·British Journal of Pharmacology·E Marley, G Nistico
Jan 1, 1973·Revue Roumaine De Physiologie = Romanian Journal of Physiology·I HaulicăA Busuioc
Jun 15, 1980·Biochemical Pharmacology·B B Fredholm, P Hedqvist
Apr 16, 1982·Neuroscience Letters·T ZetterströmB B Fredholm
Nov 17, 1980·Brain Research·M RadulovackiG Yanik
Mar 1, 1995·Progress in Neurobiology·J H Benington, H C Heller
Oct 29, 1993·Science·M SteriadeT J Sejnowski
Mar 22, 1993·The Journal of Comparative Neurology·I GrittiB E Jones
Jan 1, 1954·The Journal of Physiology·W FELDBERG, S L SHERWOOD
Jul 20, 2012·Physiological Reviews·Ritchie E BrownRobert W McCarley

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Citations

Nov 9, 2002·Microscopy Research and Technique·Hae Young ChungByung Pal Yu
Apr 13, 2001·Microscopy Research and Technique·D J Williamson, R J Hargreaves
Mar 10, 2007·Cellular and Molecular Life Sciences : CMLS·T W BoonstraP J Beek
Jul 29, 2008·Psychopharmacology·Andrey KostinTarja Porkka-Heiskanen
Jul 6, 2005·Journal of Neural Transmission·H Bartosik-Psujek, Z Stelmasiak
Jun 1, 2006·Journal of Neural Transmission·M M Edwards, S R Robinson
Dec 31, 2003·Neuroscience·E Murillo-RodriguezP J Shiromani
Jan 31, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jaime M Monti, Héctor Jantos
Jul 11, 2002·Brain Research·Mahesh M ThakkarRobert W McCarley
Mar 7, 2001·European Journal of Pharmacology·K J ElliottM A Rea
Aug 1, 1998·European Journal of Pharmacology·S SatohO Hayaishi
Jan 19, 2000·Pharmacology, Biochemistry, and Behavior·S W Wurts, D M Edgar
Dec 28, 1999·Brain Research. Brain Research Reviews·J L Moreau, G Huber
Mar 3, 2001·Acta Neurologica Scandinavica·S NagarB K Thelma
Apr 24, 1999·The European Journal of Neuroscience·S SatohO Hayaishi
Nov 18, 2003·Artificial Organs·Wentai LiuGuoxing Wang
Sep 25, 2001·Neuroreport·A RizziG Calò
Dec 1, 2004·Neuroreport·Rong WangShu-Li Sheng
Dec 29, 2000·Clinical Nuclear Medicine·R TatlidilH Mayberg
Jan 6, 2004·International Ophthalmology Clinics·Deeba Husain, John I Loewenstein
Dec 4, 2004·International Ophthalmology Clinics·Robert I Park
Feb 7, 2002·Optometry and Vision Science : Official Publication of the American Academy of Optometry·James R DroverRussell J Adams
Mar 20, 2002·Shock·Eileen M BulgerRonald V Maier
Jun 16, 2010·Clinical Nuclear Medicine·Nobuhiko MiyazawaMasataka Hayashi
Dec 6, 2008·Neuroreport·Kazuyuki ImamuraYasuyoshi Watanabe

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