Role of adherence in pathogenesis of Enterococcus faecalis urinary tract infection and endocarditis.

Infection and Immunity
C A GuzmànL Calegari

Abstract

Enterococcus faecalis strains isolated from urinary tract infections (UTIs) and endocarditis were analyzed for their ability to adhere to urinary tract epithelial cells (ECs) and Girardi heart (GH) and human embryonic kidney (HEK) cell cultures. UTI isolates adhered to urinary tract ECs more efficiently than to the cultured cells, at the same time showing the least affinity for GH cells. In contrast, endocarditis isolates adhered to GH cell cultures more readily than to urinary tract ECs. Moreover, although strains isolated from endocarditis adhered to GH cells more efficiently than those derived from UTI, the latter strains adhered to urinary tract cells better than the former. Studies of the ability of GH and HEK cells to internalize E. faecalis showed that for UTI isolates, 9 to 74% of adhered bacteria were internalized, while for endocarditis isolates, the percentage varied from 76 to 82%. All strains were able to associate with human neutrophils; endocarditis strains, however, associated less efficiently than UTI isolates. Growth in serum raised the adherence of all tested strains by at least 1.5- to 3-fold, with the greatest increase being observed in UTI strain adherence to GH cells (8-fold). In contrast, the association...Continue Reading

References

Jan 1, 1977·Annual Review of Medicine·J N SipesE W Hook
Apr 1, 1979·Infection and Immunity·F J SilverblattS Schauer
Dec 1, 1975·The Journal of Clinical Investigation·K GouldJ P Sanford
Jan 1, 1985·The Journal of Antimicrobial Chemotherapy·A Dalhoff
Jan 1, 1985·Annual Review of Microbiology·M R Brown, P Williams
Jan 1, 1984·Infection and Immunity·V Väisänen-RhenT K Korhonen
Feb 9, 1961·The New England Journal of Medicine·M G KOENIG, D KAYE

❮ Previous
Next ❯

Citations

Nov 30, 2000·Current Infectious Disease Reports·J K McCormickP M Schlievert
Oct 1, 1993·The Annals of Pharmacotherapy·S A TailorM J Rybak
Jan 1, 1997·Scandinavian Journal of Infectious Diseases·J L Pérez-CastrillonV Herreros
Sep 26, 2001·Applied and Environmental Microbiology·A Toledo-AranaI Lasa
Jan 22, 2011·Molecular Nutrition & Food Research·Micha HoffmannDirk Haller
Jun 19, 2015·Journal of Applied Microbiology·B G-C LopezA C H F Sawaya
Dec 1, 1999·Avian Pathology : Journal of the W.V.P.A·W J M LandmanD J Mevius
May 1, 1995·Current Microbiology·M da G Carvalho, L M Teixeira
Apr 26, 2013·International Urology and Nephrology·Katsumi ShigemuraMasato Fujisawa
Oct 7, 2009·Journal of Applied Microbiology·A R CarlosR Tenreiro
Feb 26, 1999·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·W J LandmanE Gruys
May 4, 1999·Infection and Immunity·C R Gentry-WeeksJ M Keith
Sep 30, 1998·FEMS Immunology and Medical Microbiology·J XiaoB E Murray
Mar 20, 2002·Research in Microbiology·Christine ArchimbaudBernard Joly
Jun 5, 1999·International Journal of Food Microbiology·C M FranzM E Stiles
Apr 25, 2013·Journal of Endodontics·Yaguang TianZhengmei Lin
Dec 22, 2006·Journal of Clinical Microbiology·Constantine TsigrelisLarry M Baddour
Oct 1, 1994·Clinical Microbiology Reviews·B D JettM S Gilmore
Jul 13, 2019·Microbiology Spectrum·Elizabeth FioreMichael S Gilmore
Oct 8, 2004·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·Güven Kayaoglu, Dag Ørstavik

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.