PMID: 8589340Jan 1, 1995Paper

Role of adhesion between activated macrophages and endothelial cells in the development of two types of massive hepatic necrosis in rats

Journal of Gastroenterology and Hepatology
S MochidaK Fujiwara

Abstract

Sinusoidal endothelial cell damage is produced by activation of hepatic macrophages after endotoxin administration in rats pretreated with Cornyebacterium parvum or undergoing 70% hepatectomy. Such damage causes fibrin deposition in the hepatic sinusoids leading to massive hepatic necrosis. In the C. parvum model, cytotoxic mediators, such as tumour necrosis factor (TNF)alpha and superoxide anions released from activated hepatic macrophages directly destroy sinusoidal endothelial cells. In contrast, in the partial hepatectomy model, endothelial cell damage occurs as a result of fibrin deposition due to derangement of the coagulation equilibrium regulated by tissue factor and thrombomodulin expressed on hepatic macrophages and sinusoidal endothelial cells, respectively. Immunohistological examination revealed that the expression of ICAM-1 in sinusoidal endothelial cells and LFA-1 in hepatic macrophages was greater in both models than in normal rats preceding the development of hepatic necrosis. The extent of liver injury was significantly attenuated by treatment with monoclonal antibodies against both adhesion molecules in the C. parvum model, but aggravated in the partial hepatectomy model, compared to control rats. We conclude...Continue Reading

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Citations

May 7, 2010·The Journal of Surgical Research·Hirochika MakinoYoshihide Hayashizaki
Apr 27, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Keiichi FujiwaraOsamu Yokosuka
Nov 14, 1997·The Journal of Surgical Research·E S FoxT F Tracy
Jul 24, 2012·Immunology Letters·Qiao YangZhi Chen
Jun 11, 2004·Liver International : Official Journal of the International Association for the Study of the Liver·Gabriëlle G M PinkseEmile De Heer
Jan 13, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M AraiK Fujiwara
Sep 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T KaidoM Imamura
Apr 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S MochidaK Fujiwara
Sep 1, 1998·Journal of Gastroenterology and Hepatology·Keiko ToshimaKenji Fujiwara

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