Role of adhesion molecules in the development of massive hepatic necrosis in rats

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
S MochidaK Fujiwara

Abstract

Massive hepatic necrosis develops after endotoxin administration in rats pretreated with heat-killed Propionibacterium acnes as a result of microcirculatory disturbance caused by endothelial cell destruction by activated macrophages in the hepatic sinusoids. Immunohistochemical hepatic expression of intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen 1 alpha (LFA-1 alpha) and the effect of monoclonal antibodies against both adhesion molecules on liver necrosis provoked after endotoxin administration was studied in these rats. There were increased stains of ICAM-1 in endothelial cells and LFA-1 alpha in macrophages in the hepatic sinusoids in Propionibacterium acnes-pretreated rats compared with normal rats. Such stains were further increased soon after endotoxin administration, followed by development of hepatic necrosis. Monoclonal antibodies against both adhesion molecules significantly attenuated the extent of liver injury compared with controls, without affecting the infiltration and activation of hepatic macrophages. Polyclonal antibodies against polymorphonuclear leukocytes eradicated circulating neutrophils, but did not change such liver injury, although gum arabic, which suppressed macr...Continue Reading

Citations

Sep 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T KaidoM Imamura
May 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S KobayashiS Todo
Jun 22, 2002·Journal of Hepatology·Takashi KobayashiMasatoshi Makuuchi
May 26, 1999·Infectious Disease Clinics of North America·C Parent, P Q Eichacker
Oct 7, 2000·Journal of Gastroenterology and Hepatology·M OhtsukaN Nakajima
Oct 13, 2006·Current Opinion in Infectious Diseases·E Ingham
Nov 1, 2001·Clinical and Diagnostic Laboratory Immunology·M YamaguchiT Kuwata
Apr 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S MochidaK Fujiwara
Aug 2, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Badreldin H AliGerald Blunden
Jul 29, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ichiro OgushiJiro Fujimoto
Oct 27, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Jeong-Hoon LeeHyo-Suk Lee
Apr 23, 2004·Life Sciences·Shaaban A Mousa
Jan 8, 1999·The Journal of Surgical Research·G S SmithT A Miller
Jun 10, 1998·Biochemical and Biophysical Research Communications·K ToshimaK Fujiwara
Jul 24, 2012·Immunology Letters·Qiao YangZhi Chen
Dec 6, 2000·The Journal of Surgical Research·G Martinez-MierP A Ward
Aug 10, 1999·Journal of Gastroenterology and Hepatology·K IwataM Kitajima

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Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.