Role of adiponectin and leptin on body development in infants during the first year of life

Italian Journal of Pediatrics
Elena BozzolaMauro Bozzola

Abstract

The control of growth and nutritional status in the foetus and neonate is a complex mechanism, in which also hormones produced by adipose tissue, such as adiponectin and leptin are involved. The aim of this study was to evaluate levels of adiponectin, leptin and insulin in appropriate (AGA) and small for gestational age (SGA) children during the 1st year of life and to correlate these with auxological parameters. In 33 AGA and 29 SGA infants, weight, length, head circumference, glucose, insulin, adiponectin and leptin levels were evaluated at the second day of life, and at one, six and twelve months, during which a portion of SGA could show catch-up growth (rapid growth in infants born small for their gestational age). Both total and isoform adiponectin levels were comparable between AGA and SGA infants at birth and until age one year. These levels significantly increased from birth to the first month of life and then decreased to lower values at 1 year of age in all subjects. Circulating leptin concentrations were higher in AGA (2.1 +/- 4.1 ng/ml) than in SGA neonates (0.88 +/- 1.03 ng/ml, p < 0.05) at birth, then similar at the 1st and the 6th month of age, but they increased in SGA from six months to one year, when they show...Continue Reading

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Jun 19, 2019·Journal of Physiology and Biochemistry·A LénizI Díez-López
Nov 15, 2016·Fetal and Pediatric Pathology·Svetlana MilenkovićBiljana Otašević

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Methods Mentioned

BETA
SGA
ELISA

Software Mentioned

Statistica

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