Role of adjuvant chemotherapy in the treatment of invasive carcinoma of the urinary bladder

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
M A Dimopoulos, L A Moulopoulos

Abstract

The standard treatment for patients with muscle-invasive carcinoma of the urinary bladder is radical cystectomy. While radical cystectomy cures many patients with this tumor, almost 50% of them will develop metastatic disease. Adjuvant chemotherapy has been proposed for these patients in an attempt to reduce the probability of relapse and to improve survival. To assess whether adjuvant chemotherapy does benefit patients with muscle-invasive bladder cancer, we reviewed all phase II and III studies published in the English literature over the last 20 years. A review of all published reports was facilitated by the use of Medline computer search and by manual search of the Index Medicus. Several comparative, nonrandomized studies have indicated that adjuvant chemotherapy may prolong disease-free survival. Four randomized studies have been conducted and all had a suboptimal patient accrual. Three studies used a cisplatin-containing combination chemotherapy and included primarily patients with non-organ-confined transitional-cell carcinoma (TCC) of the bladder. All three studies indicated that adjuvant chemotherapy improved disease-free survival and two of them also showed improvement in event-free survival and overall survival, resp...Continue Reading

Citations

Jun 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A BamiasM A Dimopoulos
May 7, 2015·BMC Cancer·Zhiling ZhangFangjian Zhou
Apr 9, 2001·Cancer Investigation·D J Vaughn, S B Malkowicz
Apr 9, 2009·Journal of the National Cancer Institute·Brent K HollenbeckJohn D Birkmeyer
Dec 1, 1999·Current Opinion in Urology·D Schultz-Lampel, A Lampel
Feb 14, 2002·Critical Reviews in Oncology/hematology·Filippo de BraudCora N Sternberg
Oct 6, 2000·Urology·M R Feneley, M Schoenberg
May 18, 2004·Cancer Treatment Reviews·John D ChesterAndrew S Protheroe

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.