Role of Adjuvant Therapy for Stage IA Serous and Clear Cell Uterine Cancer: Is Observation a Valid Strategy?

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Vikram VelkerEric Leung

Abstract

The adjuvant treatment of early stage IA serous and clear cell carcinomas of the uterus is controversial. The aims of the study were to report on a single institution experience treating these high-risk early uterine cancers and to identify women who may be suitable for observation alone. A retrospective review of patients presenting from 2003 to 2013 with pathologic stage IA (International Federation of Gynecology and Obstetrics 2009) serous or clear cell uterine carcinoma was performed. Patient and disease characteristics, surgical staging, treatment details, and recurrence data were collected. Recurrence rates and 5-year actuarial estimates of recurrence free survival (RFS) were the primary outcomes of interest. A total of 77 patients with stage IA were identified. Median (range) follow-up was 34 (1-108) months. Staging lymphadenectomy was performed in 83%. Adjuvant treatment was given to 27 patients, whereas 50 underwent observation. There were 12 recurrences total, with the 5-year RFS 79% for the cohort, with no statistically significant difference between observation and adjuvant treatment. Only 4 patients received adjuvant chemotherapy and none recurred. In the observation cohort, the presence versus absence of myometria...Continue Reading

References

Dec 17, 2003·Gynecologic Oncology·Brian M SlomovitzKaren H Lu
Dec 8, 2004·Gynecologic Oncology·William T CreasmanPeter Boyle
Dec 7, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marcus E RandallUNKNOWN Gynecologic Oncology Group Study
Aug 9, 2006·Current Opinion in Oncology·Peter E Schwartz
Mar 16, 2007·Gynecologic Oncology·Laura J HavrileskyPaola A Gehrig
Sep 26, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·J S KwonM S Carey
Nov 27, 2008·Journal of the National Cancer Institute·Pierluigi Benedetti PaniciCostantino Mangioni
Mar 24, 2009·Cancer·Amanda Nickles FaderUNKNOWN Uterine Papillary Serous Carcinoma (UPSC) Consortium
Apr 7, 2009·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·William Creasman
Apr 16, 2009·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Sergio Pecorelli
Jul 14, 2009·Gynecologic Oncology·David M BorutaAlexander B Olawaiye
Jul 14, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Thomas HogbergGunnar Kristensen
Oct 15, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Ali MahdaviMichael L Berman
Jan 26, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Shelly SewardSudeshna Bandyopadhyay
Jul 4, 2012·Journal of Muscle Research and Cell Motility·Abbey E WeithDavid M Warshaw
Sep 25, 2012·Gynecologic Oncology·Marcela G del CarmenJohn O Schorge
Mar 15, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Raphael YechieliMohamed A Elshaikh
May 3, 2013·Nature·Cyriac KandothDouglas A Levine
Nov 14, 2013·Gynecologic Oncology·Louis J M van der PuttenJanice S Kwon
Jan 15, 2014·International Journal of Radiation Oncology, Biology, Physics·Mohamed A ElshaikhAdnan Munkarah
Mar 4, 2014·Journal of the National Comprehensive Cancer Network : JNCCN·Wui-Jin KohMiranda Hughes

❮ Previous
Next ❯

Citations

May 26, 2017·Journal of Gynecologic Oncology·Toru SugiyamaHiroaki Itamochi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adenocarcinoma, Clear Cell

Clear Cell Adenocarcinoma is a tumor that arises in the female genital tract and is characterized by cells that appear clear under the microscope. Discover the latest research here.