Role of Advanced Glycation End Products on Aortic Calcification in Patients with Type 2 Diabetes Mellitus

Journal of Clinical Medicine
Pilar SanchisLuis Masmiquel

Abstract

The aim of this study was to evaluate the relationship between serum levels of advanced glycation end products (AGEs) and abdominal aortic calcification (AAC) in patients with type 2 diabetes mellitus (DM2). This was a prospective cross-sectional study. One-hundred and four consecutive patients with DM2 were given lateral lumbar X-rays in order to quantify abdominal aortic calcification (AAC). Circulating levels of AGEs and classical cardiovascular risk factors were determined. Clinical history was also registered. Patients with higher AGEs values had higher grades of aortic calcification and higher numbers of diabetic-related complications. Multivariate logistic regression analysis showed that being older, male and having high levels of AGEs and triglycerides were the independent risk factors associated to moderate-severe AAC when compared to no-mild AAC. Our results suggest that AGEs plays a role in the pathogenesis of aortic calcifications. In addition, the measurement of AGEs levels may be useful for assessing the severity of AAC in the setting of diabetic complications.

References

Jan 1, 1995·Annual Review of Medicine·M Brownlee
Sep 27, 1994·Proceedings of the National Academy of Sciences of the United States of America·R BucalaH Vlassara
Aug 23, 2000·Metabolism: Clinical and Experimental·T ShimoikeH Ochi
Mar 29, 2001·Diabetologia·R SinghL Beilin
Dec 6, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Matthew A AllisonC Michael Wright
Dec 6, 2003·Hypertension·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Dec 8, 2004·Journal of the American Society of Nephrology : JASN·Cecilia M Giachelli
Jul 23, 2005·Annals of the New York Academy of Sciences·Helen Vlassara
Jul 23, 2005·Annals of the New York Academy of Sciences·Angelika BierhausPeter P Nawroth
Apr 1, 2006·Hormones : International Journal of Endocrinology and Metabolism·Melpomeni Peppa, Helen Vlassara
May 30, 2008·Frontiers in Bioscience : a Journal and Virtual Library·Felix GrasesCarles Saus
Jun 4, 2008·Circulation·Linda L Demer, Yin Tintut
Aug 5, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Eero HonkanenUNKNOWN CORD study group
Oct 9, 2008·Cardiovascular Diabetology·Robbert MeerwaldtAndries Smit
Jun 6, 2009·Antioxidants & Redox Signaling·Anne Negre-SalvayreManuel Portero-Otín
Jul 3, 2009·Journal of Vascular Research·Takahisa TanikawaYoshiya Tanaka
Jul 11, 2009·The Journal of International Medical Research·X RenN Liu
Mar 5, 2011·American Journal of Nephrology·Joseph GawdzikMarion A Hofmann Bowman
Apr 23, 2011·Journal of Atherosclerosis and Thrombosis·Toshihiro SugaMasahiko Kurabayashi
Jan 10, 2012·Gerontology·David R Sell, Vincent M Monnier
Mar 5, 2013·Calcified Tissue International·Meiting WuCecilia M Giachelli
Oct 19, 2013·Cardiovascular Diabetology·Marcelle G A van EupenCasper G Schalkwijk
Dec 2, 2014·Trends in Cardiovascular Medicine·Jane A Leopold
Feb 25, 2015·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Rosy SetiawatiGiuseppe Guglielmi
Apr 29, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Georg SchlieperJürgen Floege
Sep 28, 2015·Current Osteoporosis Reports·Neal X Chen, Sharon M Moe
Feb 11, 2016·Current Opinion in Endocrinology, Diabetes, and Obesity·Renato QuispeSteven R Jones

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray
enzyme-linked immunosorbent assay
ELISA
imaging techniques

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.