Role of afferents in the differentiation of bipolar cells in the mouse retina.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Patrick W Keeley, Benjamin E Reese

Abstract

To establish dendritic arbors that integrate properly into a neural circuit, neurons must rely on cues from the local environment. The neurons presynaptic to these arbors, the afferents, are one potential source of these cues, but the particular dendritic features they regulate remain unclear. Retinal bipolar cells can be classified by the type of photoreceptor, cone or rod, forming synaptic contacts with their dendrites, suggesting a potential role of these afferents in shaping the bipolar cell dendritic arbor. In the present investigation, the role of photoreceptors in directing the differentiation of bipolar cells has been studied using two genetically modified "coneless" and "conefull" mice. Single cone (Type 7/CB4a) and rod bipolar cells were labeled with DiI to reveal the entire dendritic arbor and subsequently analyzed for several morphological features. For both cone and rod bipolar cells, the dendritic field area, number of dendritic terminals, and stratification of terminals in the outer plexiform layer were comparable among coneless, conefull, and wild-type retinas, and the overall morphological appearance of each type of cell was essentially conserved, indicating an independence from afferent specification. The pres...Continue Reading

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Citations

Jul 28, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Felice A Dunn, Rachel O L Wong
Oct 7, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sammy C S LeeBenjamin E Reese
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Jun 24, 2014·Developmental Cell·Patrick W KeeleyBenjamin E Reese
Jul 22, 2010·Vision Research·Benjamin E Reese
Aug 30, 2014·Developmental Biology·Patrick W KeeleyBenjamin E Reese
Jan 10, 2017·Visual Neuroscience·Patrick W KeeleyBenjamin E Reese
May 27, 2017·The Journal of Comparative Neurology·Ivan A AnastassovFelice A Dunn
Aug 12, 2014·Biological Reviews of the Cambridge Philosophical Society·Benjamin E Reese, Patrick W Keeley
May 2, 2017·Annual Review of Neuroscience·Chi ZhangRebecca E James
May 25, 2021·Frontiers in Cellular Neuroscience·Christopher M WhitakerStephen C Massey

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