Role of Aging and Hippocampus in Time-Place Learning: Link to Episodic-Like Memory?

Frontiers in Behavioral Neuroscience
Cornelis Kees MulderEddy A Van Der Zee

Abstract

With time-place learning (TPL), animals link an event with the spatial location and the time of day (TOD). The what-where-when TPL components make the task putatively episodic-like in nature. Animals use an internal sense of time to master TPL, which is circadian system based. Finding indications for a role of the hippocampus and (early) aging-sensitivity in TPL would strengthen the episodic-like memory nature of the paradigm. Previously, we used C57Bl/6 mice for our TPL research. Here, we used CD1 mice which are less hippocampal-driven and age faster compared to C57Bl/6 mice. To demonstrate the low degree of hippocampal-driven performance in CD1 mice, a cross maze was used. The spontaneous alternation test was used to score spatial working memory in CD1 mice at four different age categories (young (3-6 months), middle-aged (7-11 months), aged (12-18 months) and old (>19 months). TPL performance of middle-aged and aged CD1 mice was tested in a setup with either two or three time points per day (2-arm or 3-arm TPL task). Immunostainings were applied on brains of young and middle-aged C57Bl/6 mice that had successfully mastered the 3-arm TPL task. In contrast to C57Bl/6 mice, middle-aged and aged CD1 mice were less hippocampus-dr...Continue Reading

References

Nov 27, 1990·Neuroscience Letters·J KononenH Alho
Aug 21, 1995·The Journal of Comparative Neurology·M M MogaR Y Moore
Jan 1, 1995·Neuroscience and Biobehavioral Reviews·F W TurekP Zee
Mar 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·J F Guzowski, J L McGaugh
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·R BernabeuJ H Medina
Sep 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·G KempermannF H Gage
Feb 27, 2003·Acta Neurologica Scandinavica. Supplementum·Lars-Göran Nilsson
Aug 21, 2003·Neurobiology of Aging·James D ChurchillWilliam T Greenough
Jan 22, 2004·Nature Reviews. Neuroscience·Trey Hedden, John D E Gabrieli
Jun 26, 2004·Annual Review of Neuroscience·Larry R SquireRobert E Clark
Aug 17, 2005·Neurobiology of Learning and Memory·Ekrem DereMaria A De Souza Silva
Aug 30, 2005·Ageing Research Reviews·Michel A Hofman, Dick F Swaab
Sep 24, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Henriette van PraagFred H Gage
Sep 28, 2005·Brain Research. Brain Research Protocols·Ekrem DereMaria A De Souza Silva
Oct 29, 2005·Nature Genetics·Ruth ChiaElizabeth M C Fisher
Dec 24, 2005·Nature Reviews. Neuroscience·Sara N Burke, Carol A Barnes
Mar 21, 2007·Neuroscience and Biobehavioral Reviews·Ekrem DereMaria A De Souza Silva
May 2, 2007·Behavioral Neuroscience·Karin Van der BorghtEddy A Van der Zee
Sep 4, 2007·Progress in Brain Research·David G AmaralPierre Lavenex
Oct 9, 2007·The Journal of Experimental Biology·Mario PahlShaowu Zhang
Mar 22, 2008·Journal of Circadian Rhythms·Daan R van der VeenRoelof A Hut
Jun 3, 2008·Current Biology : CB·Eddy A Van der ZeeMenno P Gerkema
Jun 17, 2008·Neuroscience·A TrevesE I Moser
Aug 28, 2009·Current Opinion in Pulmonary Medicine·Eddy A Van der ZeeRoelof A Hut
Jan 22, 2010·Journal of Neuroendocrinology·A KalsbeekR M Buijs
Dec 1, 2010·Behavioural Brain Research·R A Hut, E A Van der Zee
Dec 7, 2010·Behavioural Brain Research·Robbert HavekesEddy A Van der Zee
May 28, 2011·Hippocampus·Sudarshan S PatilGert Lubec
Mar 8, 2012·Nature Reviews. Neuroscience·Anna A Kondratova, Roman V Kondratov
Jun 16, 2012·Frontiers in Aging Neuroscience·Naohide Yamamoto, Gregory J Degirolamo

❮ Previous
Next ❯

Citations

Jan 25, 2020·BioMed Research International·Aliz Judit ErnyeyIstván Gyertyán

❮ Previous
Next ❯

Software Mentioned

GraphPad
Excel
GraphPad Prism

Related Concepts

Related Feeds

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.