Role of AIM2 inflammasome in inflammatory diseases, cancer and infection

European Journal of Immunology
Bhesh Raj SharmaThirumala-Devi Kanneganti

Abstract

AIM2 is a cytosolic innate immune receptor which recognizes double-stranded DNA (dsDNA) released during cellular perturbation and pathogenic assault. AIM2 recognition of dsDNA leads to the assembly of a large multiprotein oligomeric complex termed the inflammasome. This inflammasome assembly leads to the secretion of bioactive interleukin-1β (IL-1β) and IL-18 and induction of an inflammatory form of cell death called pyroptosis. Sensing of dsDNA by AIM2 in the cytosol is crucial to mediate protection against the invading pathogens including bacteria, virus, fungi and parasites. AIM2 also responds to dsDNA released from damaged host cells, resulting in the secretion of the effector cytokines thereby driving the progression of sterile inflammatory diseases such as skin disease, neuronal disease, chronic kidney disease, cardiovascular disease and diabetes. Additionally, the protection mediated by AIM2 in the development of colorectal cancer depends on its ability to regulate epithelial cell proliferation and gut microbiota in maintaining intestinal homeostasis independently of the effector cytokines. In this review, we will highlight the recent progress on the role of the AIM2 inflammasome as a guardian of cellular integrity in mo...Continue Reading

References

Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Apr 17, 2004·The Journal of Investigative Dermatology·Joanna ShepherdMartin J H Nicklin
Mar 15, 2005·Gastroenterology·Karsten SchulmannUNKNOWN German HNPCC Consortium
Jan 13, 2006·Nature·Thirumala-Devi KannegantiGabriel Núñez
Apr 25, 2007·The Journal of Experimental Medicine·Thomas HenryDenise M Monack
Jul 16, 2008·Journal of Cellular and Molecular Medicine·Adrienne M Gorman
Sep 26, 2008·Journal of the American Society of Nephrology : JASN·Huiling WuSteven J Chadban
Jan 23, 2009·Nature Immunology·Tilmann BürckstümmerGiulio Superti-Furga
Oct 2, 2009·International Journal of Cancer. Journal International Du Cancer·Georgios PatsosSusanne Dihlmann
Mar 23, 2010·Cell·Osamu Takeuchi, Shizuo Akira
Mar 25, 2010·European Journal of Immunology·Sarah KimVeit Hornung
Mar 31, 2010·Nature Immunology·Vijay A K RathinamKatherine A Fitzgerald
Mar 31, 2010·Nature Immunology·Teresa Fernandes-AlnemriEmad S Alnemri
May 12, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jonathan W JonesDenise M Monack
May 22, 2010·Journal of Clinical Immunology·Jianghong WuEmad S Alnemri
Jun 22, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sarah E WarrenAlan Aderem
Jun 23, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kohsuke TsuchiyaMasao Mitsuyama
May 13, 2011·Science Translational Medicine·Yvonne DombrowskiJürgen Schauber
Sep 10, 2011·Cellular Microbiology·Kamila Belhocine, Denise M Monack
Sep 21, 2011·The Journal of Biological Chemistry·Maninjay K AtianandJonathan A Harton
Oct 1, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rendong FangMasao Mitsuyama
Feb 3, 2012·Cold Spring Harbor Perspectives in Biology·Kim Newton, Vishva M Dixit
Apr 5, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jianning GeFeng Shao
Jun 15, 2012·International Immunology·Hiroyuki SaigaKiyoshi Takeda
Aug 9, 2012·BMC Evolutionary Biology·Jasmyn A CridlandKatryn J Stacey
Oct 10, 2012·The Journal of Experimental Medicine·Rebecca L BrunetteDaniel B Stetson
Nov 23, 2012·Experimental Dermatology·Heleen D de KoningJoost Schalkwijk
Mar 6, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marco Tulio R GomesSergio C Oliveira
Jun 15, 2013·Archives of Dermatological Research·M ReinholzJ Schauber
Jul 12, 2013·Mediators of Inflammation·Abhishek ShastriUday Kishore
Aug 30, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·John J KaminskiKatherine A Fitzgerald
Oct 16, 2013·Infection and Immunity·Eunjoo ParkJin Chung
Dec 24, 2013·Nature Reviews. Immunology·Lionel B Ivashkiv, Laura T Donlin
Jan 9, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Stephanie E AdamczakRobert W Keane
Feb 4, 2014·Journal of Neurochemistry·Richa HanamsagarTammy Kielian

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Citations

Feb 7, 2020·Pigment Cell & Melanoma Research·Abdullah Al EmranPeter Hersey
May 14, 2020·Journal of Leukocyte Biology·Lalita Mazgaeen, Prajwal Gurung
May 30, 2020·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Li RongPinfang Kang
Sep 26, 2020·Frontiers in Physiology·Hana StarobovaIrina Vetter
Jul 28, 2020·Immunological Reviews·Puja KumariVijay A Rathinam
Jul 25, 2020·Journal of Hematology & Oncology·Chaeuk ChungEun-Kyeong Jo
Aug 17, 2020·International Journal of Molecular Sciences·Giulia PoliStefano Brancorsini
Aug 6, 2020·International Journal of Molecular Sciences·Marianne R SpalingerMichael Scharl
May 2, 2020·Journal of Molecular Histology·Shanshan LiuMinqi Li
Oct 31, 2020·Frontiers in Immunology·Nikolaos I VlachogiannisPetros P Sfikakis
Dec 3, 2020·Frontiers in Cardiovascular Medicine·Enzo LüsebrinkAlexander Otto Krogmann
Jan 24, 2021·Cardiovascular Research·Masafumi Takahashi
Oct 30, 2020·Frontiers in Immunology·Maja Wyczanska, Bärbel Lange-Sperandio
Apr 16, 2021·Advanced Drug Delivery Reviews·M Brittany JohnsonKirill A Afonin
May 21, 2021·Immunity, Inflammation and Disease·Huan ZhuHaijing Wu
Jun 3, 2021·International Journal of Molecular Sciences·Magdalena CiążyńskaAleksandra Lesiak
Jun 13, 2021·Seminars in Cancer Biology·Ali Talha KhalilHari Parsad Devkota
Aug 16, 2021·Current Opinion in Immunology·David A ConstantIsabella Rauch
Sep 3, 2021·Nature·SangJoon LeeThirumala-Devi Kanneganti
Sep 3, 2021·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Vitor Pedro TarghettaNiels Olsen Saraiva Camara
Sep 3, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yujin HongKwangseog Ahn

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