Role of AKT kinase in measles virus replication.

Journal of Virology
Mary CarsilloStefan Niewiesk

Abstract

Many RNA and DNA viruses activate serine-threonine kinase AKT to increase virus replication. In contrast, measles virus (MV) infection leads to downregulation of AKT. This is thought to be beneficial for the virus because it correlates with immune suppression. To determine whether this is a sacrifice for the virus, we used a recombinant virus and transfected cells expressing constitutively active AKT and evaluated its effect on virus replication. In vitro, overexpression of AKT did not influence virus replication but did affect (cell-type dependent) virus release. In vivo, the recombinant virus did not abrogate inhibition of proliferation of spleen cells from MV-infected cotton rats.

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Citations

Apr 9, 2010·Medical Microbiology and Immunology·Elita AvotaSibylle Schneider-Schaulies
Aug 19, 2011·Journal of Virology·John-Sebastian EdenAndrew J Brown
Jan 24, 2016·Antiviral Research·Alan BaerKylene Kehn-Hall
Aug 17, 2014·Biochemical and Biophysical Research Communications·V Ayala-PeñaL Scolaro
May 28, 2016·Viruses·Valerie Le SageAndrew J Mouland
Aug 3, 2020·Archives of Virology·Javier BlancoIsabel Muñoz-Barroso

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