Role of alpha 1- and alpha 2-adrenoceptors in the modulation of the baroreflex vagal bradycardia

European Journal of Pharmacology
A M HuchetH Schmitt

Abstract

Yohimbine (100 micrograms/kg), an alpha 2-adrenoceptor blocking agent when injected into the vertebral artery of anaesthetized dogs decreased the vagally mediated bradycardia induced by carotid sinus nerve stimulation. Intracisternal administration of phenylephrine (30 micrograms/kg) an alpha 1-adrenoceptor agonist decreased, whereas AR-C 239 (5 micrograms/kg) and prazosin (5 micrograms/kg) two potent alpha 1-adrenoceptor antagonists injected into the vertebral artery, potentiated the bradycardiac response. These results suggest the presence of two types of alpha-adrenoceptors to modulate the baroreceptor pathway: alpha 1-adrenoceptors inhibit and alpha 2-adrenoceptors facilitate the transmission of baroreceptor impulses.

Citations

Jan 1, 1989·Fundamental & Clinical Pharmacology·C Damase-MichelP Montastruc
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Apr 1, 1989·Cardiovascular Drugs and Therapy·P A van Zwieten
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Aug 16, 2016·Journal of Clinical Monitoring and Computing·Theodosios SaranteasFotios Panou

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