Role of alteration in Treg/Th17 cells' balance in nephropathic patients with Type 2 diabetes mellitus

Electronic Physician
Sameh Abouzeid, Nevine Sherif

Abstract

In type 2 diabetes mellitus, the adaptive immune system drives systemic inflammation, promoting insulin resistance and related complications, such as diabetic nephropathy. Increased infiltration of activated T lymphocytes has been found in patients with diabetic nephropathy. T-cell influx and accumulation are the factors that aggravate diabetic nephropathy and link with glomerular filtration surface and albumin excretion. An appropriate balance between pro-inflammatory (T helper 17: Th17, and T helper 1: Th1) and anti-inflammatory (regulatory T cells: Tregs) subsets of T cells is critical to maintain homeostasis and avoid inflammatory disease. The aim of this study was to determine the balance between T helper 17 and regulatory T cells in type 2 diabetic patients who have diabetic nephropathy. This case control study was conducted between December 2013 and June 2014 in Theodor Bilharz Research Institute in Egypt. Forty patients and 20 healthy volunteers were recruited in the study, and three groups were formed, i.e. two groups of cases with 20 patients in each group and one group of 20 controls) The groups were 1) 20 type 2 diabetic patients with nephropathy (group A); 2) 20 type 2 diabetic patients without nephropathy (group B...Continue Reading

Citations

Mar 3, 2017·Journal of Diabetes Research·Chang XiaJixin Zhong
Sep 30, 2016·World Journal of Transplantation·Periklis DousdampanisAthanasia Mouzaki
Feb 28, 2018·Clinical & Translational Immunology·Maliha A AlikhanJoshua D Ooi
Mar 2, 2021·Best Practice & Research. Clinical Endocrinology & Metabolism·Matthew SnelsonMelinda T Coughlan
May 13, 2021·Human Gene Therapy·Weidong QinXiao Meng
Jul 30, 2021·Frontiers in Immunology·Siwen ZhangGuixia Wang
Aug 3, 2021·Computers in Biology and Medicine·M Babul IslamMohammad Ali Moni

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Methods Mentioned

BETA
flow cytometry

Software Mentioned

SPSS

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