Role of alveolar macrophage-T cell adherence in accessory cell function in human immunodeficiency virus-infected individuals

American Journal of Respiratory Cell and Molecular Biology
Homer L Twigg, D M Soliman

Abstract

Previous work has shown that alveolar macrophages (AM) from human immunodeficiency virus (HIV)-infected patients are superior accessory cells (AC) and secrete greater amounts of T cell-stimulatory cytokines than do normal AM. We now examine the role of AM-T cell adherence in AM AC function by examining the ability of beta 2 integrins and intercellular adhesion molecule-1 (ICAM-1) to block adherence and lymphoproliferation. Mitogen-induced (concanavalin A, pokeweed mitogen) adhesion and proliferation were studied in the presence and absence of mAb directed against beta 2 integrins and ICAM-1. AM from normal subjects and HIV-positive patients were used as AC, and normal T cells were used as responders. Normal and HIV AM bound equal numbers of T cells under similar conditions. Adherence was blocked by antibodies to beta 2 integrins and ICAM-1 in both groups. Con A-induced lymphoproliferation was positively correlated with adherence in normal volunteers. In contrast, greater Con A-induced AM-T cell adherence in HIV-positive patients was associated with worse AC function. Antibodies that impaired AM-T cell adherence completely inhibited AC function in both groups when added at the beginning of mitogen assays, indicating that initial...Continue Reading

Citations

Aug 1, 1996·Immunology Today·C AgostiniG Semenzato
May 6, 1999·American Journal of Respiratory and Critical Care Medicine·H L TwiggC T Schnizlein-Bick
Oct 6, 2000·American Journal of Respiratory Cell and Molecular Biology·W J Martin, R Pasula
Sep 16, 2003·American Journal of Respiratory Cell and Molecular Biology·Richard B DayHomer L Twigg
Oct 24, 2013·Reviews in Medical Virology·Cecilia T Costiniuk, Mohammad-Ali Jenabian
Dec 1, 1996·Clinics in Chest Medicine·C Agostini, G Semenzato
Jun 19, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·J E Castañeda-DelgadoB Rivas-Santiago
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Feb 2, 2002·Health Care for Women International·Marcia Hills, Jennifer Mullett
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Feb 10, 1999·The American Journal of Physiology·H L TwiggG K Iwamoto

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