Role of amino acids in insulin signaling in adipocytes and their potential to decrease insulin resistance of adipose tissue

The Journal of Nutritional Biochemistry
Charlotte HinaultIsabelle Mothe-Satney

Abstract

Recently, our knowledge concerning the role of amino acids in signal transduction in mammals has greatly improved. This significant advance is mainly due to the remarkable discovery that the mammalian target of rapamycin (mTOR) protein kinase, known to be activated in response to a large number of hormones, growth factors and cytokines, is also under the tight control of branched-chain amino acids. Actually, both inputs are necessary to fully activate the mTOR pathway, the main function of which is to increase cell size, via the regulation of translational processes. However, amino acids are able to modulate other biological effects and appear to have unexpected actions, as evidenced by our recent work in rat adipocytes. The aim of this review is to summarize novel findings on the role of mTOR and amino acids in insulin signaling in adipocytes. A possible beneficial impact of the use of amino acids in the treatment of insulin resistance is discussed, and hypotheses about the molecular mechanisms underlying their effect are proposed.

References

Mar 21, 2000·Journal of Cellular Biochemistry·C J LynchS R Kimball
Apr 5, 2000·The Journal of Biological Chemistry·C C KingG M Bokoch
Aug 13, 2002·Nature Cell Biology·Xinsheng GaoDuojia Pan
Jan 15, 2004·Diabetologia·L PirolaE Van Obberghen
Mar 17, 2004·Biochemical and Biophysical Research Communications·Christian J CarlsonCristina M Rondinone
Apr 20, 2004·Current Opinion in Clinical Nutrition and Metabolic Care·Scot R Kimball, Leonard S Jefferson
Oct 14, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Charlotte HinaultEmmanuel Van Obberghen
Dec 9, 2004·Current Opinion in Clinical Nutrition and Metabolic Care·Joseph AvruchSara Ortiz-Vega
Jan 18, 2005·Trends in Biochemical Sciences·Laura S HarringtonRichard F Lamb
Jan 22, 2005·Seminars in Cell & Developmental Biology·Scot R Kimball, Leonard S Jefferson
Feb 19, 2005·Science·D D SarbassovDavid M Sabatini
Mar 1, 2005·Biochimie·Philippe GualJean-François Tanti
May 10, 2005·The Journal of Biological Chemistry·Xiaomeng LongJoseph Avruch
May 25, 2005·Diabetic Medicine : a Journal of the British Diabetic Association·S SchinnerA Barthel
Jun 3, 2005·Current Opinion in Clinical Nutrition and Metabolic Care·Frédéric TremblayAndré Marette
Jul 29, 2005·The Journal of Biological Chemistry·Maya P ByfieldJonathan M Backer
Sep 24, 2005·Proceedings of the National Academy of Sciences of the United States of America·Takahiro NobukuniGeorge Thomas

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Citations

Dec 17, 2008·The British Journal of Nutrition·Sophie TesseraudIban Seiliez
Oct 6, 2009·Molecular and Cellular Endocrinology·Chin Fen TeoLance Wells
Oct 12, 2013·Epigenetics : Official Journal of the DNA Methylation Society·Andrée-Anne HoudeLuigi Bouchard
Dec 25, 2012·General and Comparative Endocrinology·Mariella B FreitasEliana C Pinheiro
Jun 4, 2016·Trends in Pharmacological Sciences·Kang YaoYulong Yin
May 17, 2018·Physiological Reviews·Sofiya GanchevaMichael Roden
Aug 1, 2007·The Journal of Biological Chemistry·Salvatore C RuffoloBrian P Kennedy
Jun 14, 2008·PLoS Computational Biology·Gunnar CedersundPeter Strålfors
Mar 5, 2019·Metabolomics : Official Journal of the Metabolomic Society·Kai YangZheng-Jiang Zhu
Sep 10, 2009·American Journal of Physiology. Endocrinology and Metabolism·Nattida ChotechuangDaniel Tomé

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