Role of AMPA and NMDA receptors on vasopressin and oxytocin secretion induced by hypertonic extracellular volume expansion

Journal of Neuroendocrinology
Tatiane Vilhena-FrancoAndre S Mecawi

Abstract

Vasopressin (AVP) and oxytocin (OT) are essential for the control of extracellular fluid osmolality and volume. Secretion of these hormones is modulated by several mechanisms, including NMDA and AMPA L-glutamate receptors in magnocellular cells of paraventricular (PVN) and supraoptic (SON) hypothalamic nuclei. Thus, to better understand the participation of L-glutamate on the neuroendocrine control of AVP and OT, this work evaluated the effects of intracerebroventricular (icv) NMDA and AMPA receptor antagonists on plasma AVP and OT levels induced by extracellular volume expansion (EVE). Cannulated rats received icv NMDA (AP5) and AMPA (NBQX) antagonists in 10 and 30nmol/5μl/rat doses and were subjected to either isotonic (0.15 M NaCl, 2ml/100g) or hypertonic (0.30 M NaCl, 2ml/100g) EVE. Blood samples were collected for plasma AVP and OT determination. Isotonic EVE did not change plasma AVP and OT levels, but hypertonic EVE increased both AVP and OT plasma levels. AP5 reduced plasma AVP, but it did not change the OT level induced by hypertonic EVE. On the other hand, NBQX reduced plasma OT, but did not alter the AVP plasma level. Our data shows that L-glutamate controls the secretion of neurohypophyseal hormones through the NMDA...Continue Reading

References

Nov 1, 1988·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·G W Bisset, H S Chowdrey
Oct 1, 1988·Physiological Reviews·L Share
Oct 1, 1973·The Journal of Clinical Endocrinology and Metabolism·M K HusainS M Glick
Mar 1, 1974·Journal of Applied Physiology·P G Harms, S R Ojeda
Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·M A HaanwinckelJ Antunes-Rodrigues
Sep 1, 1994·Frontiers in Neuroendocrinology·C W BourqueD Richard
May 1, 2001·The Journal of Comparative Neurology·O EyigorL Jennes
Jan 13, 2004·Physiological Reviews·José Antunes-RodriguesSamuel M McCann
Oct 2, 2004·The Journal of Physiology·Christiaan P J de KockArjen B Brussaard
Jan 4, 2012·Clinical and Experimental Pharmacology & Physiology·S G RuginskJ Antunes-Rodrigues
Apr 13, 2013·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J Antunes-RodriguesL L K Elias
Jul 24, 2013·Clinical and Experimental Pharmacology & Physiology·Silvia G RuginskJose Antunes-Rodrigues
Jul 4, 2015·Comprehensive Physiology·Andre de Souza MecawiJose Antunes-Rodrigues
Aug 12, 2016·Journal of Systems and Integrative Neuroscience·Christian L RothClinton Elfers

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