Oct 19, 2006

Role of amyloid precursor protein, amyloid-beta and gamma-secretase in cholesterol maintenance

Neuro-degenerative Diseases
T Hartmann

Abstract

Lipids play an important part as risk factors for Alzheimer's disease. This article summarizes the current understanding of the molecular mechanism by which amyloid-beta (Abeta) peptides regulate cholesterol and sphingomyelin metabolism, and how in return cholesterol and sphingomyelin regulate Abeta peptide production. An understanding of the physiological function of amyloid precursor protein processing and Abeta function is critical for the development of future therapeutic approaches, e.g. statin treatment.

Mentioned in this Paper

Sphingomyelin Metabolic Process
Familial Alzheimer Disease (FAD)
Epicholesterol
APP protein, human
Amyloid Beta Precursor Protein Measurement
APP wt Allele
Alzheimer's Disease
Amyloid Deposition
Amyloid
Lipids

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