Abstract
Angiogenesis plays a key role in the initiation of growth and metastatic process in cancers. The angiogenic switch may be one of the earliest events in conferring a metastatic potential to the tumor. Further evolution in this multi-step cascade is controlled by the positive and negative regulators of angiogenesis. Recent advances in molecular biology have given a better insight into the mechanisms governing head neck cancer with promising data elaborating the role of angiogenesis. Metastasis to neck nodes is a very important determinant of prognosis, and is more frequently encountered than distant metastasis in head and neck cancers. Systematic PUBMED search of English-language literature of studies involving humans between 1990 and 2008 using the Mesh terms 'pathologic neovascularization', 'head and neck neoplasms', 'lymphatic metastasis' was performed. Quality assessment of selected studies included clinical pertinence, publication in peer reviewed journals, adequate number of enrolled patients. The present article reviews the utility value of various angiogenic parameters and markers that have been utilized to predict regional metastasis including micro vessel density, positive and negative regulators of angiogenesis, and ge...Continue Reading
References
Sep 1, 1995·The Annals of Otology, Rhinology, and Laryngology·Y MiyajimaM Morimatsu
Jan 24, 1997·Cell·M S O'ReillyJ Folkman
Jul 24, 2001·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·T StuckensenR P Baum
Mar 21, 2002·Clinical Otolaryngology and Allied Sciences·J J HomerN D Stafford
Apr 5, 2002·Head & Neck·Sandro J StoeckliStephan Schmid
Dec 13, 2002·Head & Neck·Francisco J CivantosFred Moffat
Apr 5, 2003·Oral Oncology·N C HydeP Ell
Apr 5, 2003·Oral Oncology·Koji KishimotoTomohiro Matsumura
Jul 17, 2003·International Journal of Cancer. Journal International Du Cancer·Masaki NagataRitsuo Takagi
Aug 7, 2003·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Roland SedivySelma Hönigschnabl
Jan 22, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sang-Chul LimAtsushi Ochiai
Jan 28, 2004·Cancer·Mario Fernando Muñoz-GuerraCarlos Gamallo
May 8, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Henni RuokolainenTaina Turpeenniemi-Hujanen
Feb 3, 2005·Cancer·Satoshi FukataTaro Shuin
Feb 8, 2005·Oral Oncology·Tiziana MartoneGiorgio Cortesina
Sep 10, 2005·Seminars in Nuclear Medicine·Yusuf Menda, Michael M Graham
Mar 17, 2006·The Laryngoscope·Francisco J CivantosWilliam J Goodwin
Dec 5, 2006·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Ki Chang KeumGwi Eon Kim
Dec 5, 2006·International Journal of Oral and Maxillofacial Surgery·S Johnstone, R M Logan
Jan 26, 2007·Head & Neck·Beena P PatelPrabhudas S Patel
Feb 20, 2007·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Gary WarburtonSharon M Wahl
Citations
Feb 16, 2012·Electromagnetic Biology and Medicine·Juan Carlos Trivino PardoCaterina Cinti
Mar 23, 2011·The Journal of Urology·Feng FengZhouJun Shen
Oct 2, 2020·PloS One·Anna RzepakowskaKazimierz Niemczyk
Dec 24, 2018·Cancer Medicine·Michael EvansZhuo G Chen