Role of angiotensin II in the remodeling induced by a chronic increase in flow in rat mesenteric resistance arteries

Hypertension
Maud CousinLaurent Loufrani

Abstract

Angiotensin II is a potent growth factor involved in arterial wall homeostasis. In resistance arteries, chronic increases in blood flow induce a rise in diameter associated with arterial wall hypertrophy. Nevertheless, the role of angiotensin II in this remodeling is unknown. We investigated the effect of blocking angiotensin II production or receptor activation on flow-induced remodeling of mesenteric resistance arteries. Arteries were ligated in vivo to generate high-flow arteries compared with normal flow (control) vessels located at a distance. Arteries were isolated after 1 week for in vitro analysis. Arterial diameter, media surface, endothelial NO synthase expression, superoxide production, and extracellular signal-regulated kinase 1/2 phosphorylation were higher in high-flow than in control arteries. Angiotensin-converting enzyme inhibition (perindopril) and angiotensin II type 1 receptor blockade (candesartan) prevented arterial wall hypertrophy without affecting diameter enlargement. The nonselective vasodilator hydralazine had no effect on remodeling. Although perindopril and candesartan increased endothelial NO synthase expression in high-flow arteries, hypertrophy remained in rats treated with N(G)-nitro-l-arginine...Continue Reading

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Citations

Jul 30, 2010·Cellular and Molecular Life Sciences : CMLS·Kenia Pedrosa NunesR Clinton Webb
Jun 15, 2014·Pharmacology & Therapeutics·Dimitris TousoulisChristodoulos Stefanadis
Dec 24, 2014·International Journal of Molecular Sciences·Marius C StaiculescuLuis A Martinez-Lemus
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Jun 17, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Pauline RobertLaurent Loufrani
Jul 13, 2017·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Hicham Labazi, Aaron J Trask

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