Role of angiotensin receptor blockers in the prevention and treatment of arrhythmias

The American Journal of Cardiology
Shaila GargDavid Cesario

Abstract

The renin-angiotensin system is a key regulatory system that is activated in many forms of cardiovascular disease. It is well established that angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) are important therapeutic agents in the treatment of hypertension, myocardial infarction, and congestive heart failure. More recent research has suggested that renin-angiotensin system activation may also play a critical role in the genesis of atrial and ventricular arrhythmias. The possible role of renin-angiotensin system activation in arrhythmogenesis suggests that ACE inhibitors and ARBs may be important therapeutic agents in the prevention and treatment of arrhythmias. This review summarizes the current evidence for the use of ARBs in the treatment of atrial and ventricular arrhythmias.

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Citations

Feb 24, 2009·Journal of Molecular and Cellular Cardiology·Alessandra Matavel, Coeli M B Lopes
Jul 19, 2011·International Journal of Cardiology·Theresa DartschCarsten Zobel
Apr 17, 2016·European Journal of Clinical Pharmacology·Thomas H LangenickelIris Rajman
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Dec 24, 2018·International Journal of Molecular Sciences·Ronja SchiemannHeiko Meyer

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