PMID: 8827941Jan 1, 1996Paper

Role of animal danders as inhalant allergens in bronchial asthma in India

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
S GuptaM K Agarwal

Abstract

The etiological significance of animal danders in Indian patients with nasobronchial disorders has not yet been investigated. In the present study, the role of animal danders in the etiology of bronchial asthma was studied. Extracts of danders from 6 animals along with guinea pig whole pelt were prepared. Intradermal and bronchial provocation tests with these extracts were performed on (i) 68 asthmatics and (ii) 20 nonallergic healthy volunteers. In patients, significant positive skin reactions (2+ to 4+) ranged from 1.4% each with guinea pig whole pelt and ox dander to 8.8% with dog dander extracts. None of the healthy volunteers elicited such a response. On bronchial provocation, 20% and 53.8% of the tests were positive in asthmatics showing 1+ and 2+ skin reactivity, respectively. All the patients as well as controls eliciting negative intradermal responses demonstrated uniformly negative bronchial provocation tests to different dander extracts. Analysis of various clinical features of asthmatics with respect to skin positivity to dander/pelt extract was also carried out. Radioallergosorbent tests (RASTs) were performed to estimate dander-specific IgE levels in the sera of patients showing different grades of skin response t...Continue Reading

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Citations

May 22, 2001·Thorax·T MelsomM R Pandey
Aug 6, 2010·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Martin J DownesJuan P Wisnivesky
Aug 23, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B TutluogluM Yaman
Jan 13, 1999·American Journal of Industrial Medicine·M Kimbell-DunnN Pearce
Nov 30, 2006·Current Opinion in Pulmonary Medicine·Surinder K Jindal

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