Role of anti-interleukin-2 receptor antibodies in kidney transplantation

BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
D M CibrikH U Meier-Kriesche

Abstract

From the early 1960s, the mainstay of immunosuppression for kidney transplantation has been corticosteroids. Since then, many new drugs have been developed to maintain the renal allograft. Current maintenance immunosuppression commonly consists of corticosteroids, antiproliferative agents and calcineurin inhibitors (e.g. cyclosporin). More recently, antihuman antibodies, either monoclonal or polyclonal, have been developed to use for induction at the time of transplantation or to treat rejection. With the advances in molecular technology, a new class of antihuman antibodies [the anti-interleukin-2 receptor (IL-2R) antibodies] has emerged that incorporate a murine antigen-binding site on to a human immunoglobulin backbone. Such methodology creates antihuman antibodies with high affinity for the epitope and with prolonged serum antibody half-lives. Interleukin-2 and its receptor are central to lymphocyte activation and are the main targets of calcineurin inhibitors. In addition, the anti-IL-2R antibodies inhibit a key target in immune activation. Daclizumab and basiliximab have been shown to significantly reduce the incidence of acute rejection in kidney transplantation. Since these anti-IL-2R antibodies are well tolerated and si...Continue Reading

References

Feb 22, 1990·The New England Journal of Medicine·A M KrenskyP Parham
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C QueenT A Waldmann
Nov 1, 1984·Annals of Internal Medicine·D J CohenT B Strom
Aug 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M SuthanthiranT B Strom
Jun 19, 1998·The New England Journal of Medicine·M H Sayegh, L A Turka
Oct 2, 1998·Advances in Immunology·B H Nelson, D M Willerford
Mar 20, 1999·Transplantation Proceedings·F VincentiR Johnson
Sep 1, 1999·Kidney International·L C Paul
Nov 26, 1999·Transplantation·K A WilliamsH Zola
Mar 8, 2000·Transplantation·J W Kupiec-Weglinski
Jun 3, 2000·Transplant International : Official Journal of the European Society for Organ Transplantation·H U Meier-KriescheB Kaplan
Jun 3, 2000·Transplant International : Official Journal of the European Society for Organ Transplantation·H EkbergF Vincenti
Sep 27, 2000·Journal of the American Society of Nephrology : JASN·Huong T B TranEdgar L Milford
Oct 26, 2000·Clinical Transplantation·H U Meier-KriescheB Kaplan

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Citations

Nov 13, 2003·Transplantation Proceedings·F PoorrezagholiS Farhangi
Dec 4, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Shuang WangAnthony M Jevnikar
Dec 8, 2006·Expert Opinion on Biological Therapy·Carlo B Ramirez, Ignazio R Marino
May 31, 2003·Nature Reviews. Drug Discovery·Josef S Smolen, Günter Steiner
Jun 25, 2004·The British Journal of Dermatology·A RenklJ Norgauer
Jan 22, 2010·The Cochrane Database of Systematic Reviews·Angela C WebsterJonathan C Craig
Jan 11, 2017·The Cochrane Database of Systematic Reviews·Penny HillAngela C Webster
Oct 24, 2002·Current Opinion in Nephrology and Hypertension·Paul A Keown

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