Abstract
The MIC (MHC class I chain-related) genes are a group of nonclassical MHC genes, located in the MHC class 1 region of chromosome 6. The aim of the present study was to find the prevalence of MHC class 1 chain-related (MICA) alloantibodies in patients undergoing live-related donor renal transplantation and its role in short-term graft survival. The role of blood transfusion in the formation of these antibodies was also studied. Pretransplant samples of patients undergoing renal allograft transplantation were tested for anti-MICA antibodies. Association of various demographics, HLA-A + B + DRB1 mismatches, anti-HLA antibody screen, and anti-MICA antibodies was assessed using Pearson's chi-square test. Out of 646 serum samples, 94 (14.6%) were positive and 552 (85.4%) were negative for anti-MICA antibodies. Patients with anti-MICA antibody had a graft survival 89.3% as compared to 94.7% in patients without anti-MICA antibody (P < 0.05). The hazard ratio for all patients was 3.0701 (P < 0.05). Out of the 340 patients with no HLA antibodies, the presence of anti-MICA antibodies without any HLA antibodies (n = 43) was associated with poor outcome in the patients (hazard ratio of 2.768, P < 0.05). The presence of MICA antibodies with ...Continue Reading
References
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·S BahramT Spies
Jul 31, 1999·Science·S BauerT Spies
Oct 29, 2000·Human Immunology·N W ZwirnerP Stastny
Mar 28, 2002·Human Immunology·Yizhou ZouPeter Stastny
Aug 2, 2002·Transplantation·S Sumitran-HolgerssonK Söderström
May 4, 2005·Lancet·Gerhard Opelz, UNKNOWN Collaborative Transplant Study
Aug 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Kazuo MizutaniJarhow Lee
May 16, 2006·Human Immunology·Yizhou ZouPeter Stastny
Sep 28, 2006·Human Immunology·Kazuo MizutaniMiyuki Ozawa
Jan 19, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P I TerasakiR Castro
Apr 28, 2007·Human Immunology·Arundhati PanigrahiNarinder K Mehra
Sep 28, 2007·The New England Journal of Medicine·Yizhou ZouGerhard Opelz
Feb 26, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K SolezM Valente
Jan 13, 2009·Transplantation·Antonia Alvarez-MárquezAntonio Núñez-Roldán
Feb 11, 2010·Transplantation·Li LiMinnie M Sarwal
May 14, 2010·Transplantation·Anne LemyDaniel Abramowicz
Jan 5, 2011·Pediatric Transplantation·Shoba NarayanRobert B Ettenger
Dec 21, 2011·Transplant Immunology·Ghasem SolgiAli Akbar Amirzargar
Jul 14, 2012·Current Opinion in Organ Transplantation·Duska DragunRusan Catar
Dec 15, 2012·Transplantation·Brian D TaitGerhard Opelz
Apr 30, 2013·Transplantation·Elena Sánchez-ZapardielEstela Paz-Artal
Sep 2, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Elena Sánchez-ZapardielEstela Paz-Artal
Dec 1, 2015·Experimental and Molecular Pathology·Junchao CaiXin Qing
Citations
Jun 28, 2020·Scandinavian Journal of Immunology·Ajay Kumar BaranwalNarinder Mehra
Aug 9, 2019·Vaccines·Monika LindemannOliver Witzke
Nov 20, 2020·Transplantation·Tineke Kardol-Hoefnagel, Henny G Otten