Role of antioxidant systems in induced nutritional pancreatic atrophy in chicken

Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
José Luis AvanzoMarcelo de Cerqueira Cesar

Abstract

One-day-old chicks were reared using diets differing in their vitamin E and/or selenium content. The purpose of this research was to detect any possible imbalance in the antioxidant defense system, which could be related to development of nutritional pancreatic atrophy. Mitochondrial membranes from animals deficient in both nutrients, or just vitamin E, submitted to peroxidizability 'in vitro' had the production of TBARS greatly enhanced. Measurements of the 2-GSH/GSSG ratio suggested that selenium and vitamin E, the latter in higher magnitude, were responsible for maintenance of the reducing capacity of the cell. Enzymatic defense systems against oxidative stress were also studied. The results indicated that the total antioxidant enzymatic activity of pancreatic cells was not sufficient to scavenge all the ROS generated in the nutritionally deficient animals. The present study suggests that nutritional deficiency of selenium and/or vitamin E generates one imbalance between pro-oxidant and antioxidant systems in chicken pancreas, leading to oxidative stress and pancreatic atrophy.

References

Jan 1, 1978·Biochemical Pharmacology·Y Masuda, T Murano
Oct 1, 1990·Zentralblatt für Veterinärmedizin. Reihe A·S HassanJ Työppönen
Jan 1, 1988·Free Radical Biology & Medicine·L W Oberley
Jan 1, 1988·Free Radical Biology & Medicine·A Bindoli
Feb 1, 1985·Medical Hypotheses·K L Nuttall
Nov 1, 1971·Analytical Biochemistry·C Beauchamp, I Fridovich
Mar 1, 1994·Canadian Journal of Physiology and Pharmacology·M I McBurney
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·M Peled-KamarY Groner
Aug 1, 1997·Biochemistry and Molecular Biology International·R W ScholzC C Reddy
Jun 26, 1998·Free Radical Biology & Medicine·Y SagaraP Maher
Aug 26, 1998·Neuromuscular Disorders : NMD·M Pandolfo
Aug 26, 1998·Biochimica Et Biophysica Acta·M F Beal
Aug 26, 1998·Biochimica Et Biophysica Acta·A H Schapira
Jan 16, 1999·Free Radical Biology & Medicine·S M CardosoR Oliveira
Feb 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·S MelovD C Wallace
May 8, 1999·Free Radical Biology & Medicine·J M BurczynskiH D Colby
Sep 18, 1999·Free Radical Biology & Medicine·C K ChowA C Chan
Mar 4, 2000·Free Radical Biology & Medicine·W IbrahimC K Chow
Nov 23, 2000·Nature·T Finkel, N J Holbrook
May 23, 2001·Free Radical Biology & Medicine·M A PahlavaniA Richardson
Jun 26, 2001·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·J L AvanzoM de Cerqueira Cesar

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Citations

Jan 6, 2007·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Manisha A ModakSaroj S Ghaskadbi
Jul 30, 2010·Biological Trace Element Research·Nedyalka V GeorgievaIvanka Jotova
Aug 21, 2003·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Jagneshwar DandapatK Janardhana Rao
Jan 16, 2009·Archives of Animal Nutrition·Julia FischerJosef Pallauf
Dec 8, 2009·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·E ZoidisK Feggeros
Oct 24, 2006·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Nadezda A Golubkina, Tigran T Papazyan
Sep 17, 2013·Diabetes/metabolism Research and Reviews·Manisha A ModakSaroj S Ghaskadbi
Jan 27, 2018·Journal of Animal Science and Biotechnology·Ahmed Mohamed FouadChuntian Zheng

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