Role of Antioxidants in Assisted Reproductive Techniques

The World Journal of Men's Health
A Agarwal, Ahmad Majzoub

Abstract

Oxidative stress (OS) has been recognized as a significant cause of suboptimal assisted reproductive outcome. Many of the sperm preparation and manipulation procedures that are necessary in the in vitro environment can result in excessive production of reactive oxygen species (ROS) thereby exposing the gametes and growing embryos to significant oxidative damage. Antioxidants have long been utilized in the management of male subfertility as they can counterbalance the elevated levels of ROS inducing a high state of OS. Few studies have looked into the clinical effectiveness of antioxidants in patients undergoing assisted reproduction. While an overall favorable outcome has been perceived, the specific clinical indication and optimal antioxidant regimen remain unknown. The goal of our review is to explore the sources of ROS in the in vitro environment and provide a clinical scenario-based approach to identify the circumstances where antioxidant supplementation is most beneficial to enhance the outcome of assisted reproduction.

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Citations

Aug 23, 2019·Animal Biotechnology·Roberto R da Rosa FilhoCristina F Lucio
Sep 17, 2020·Reproductive Sciences·Jitender Kumar BhardwajPriyanka Saraf
May 18, 2018·The Journal of Veterinary Medical Science·Fuminori TaniharaTakeshige Otoi
Jul 26, 2018·Animal Science Journal = Nihon Chikusan Gakkaihō·Breno Fernandes Barreto SampaioCarmem Estefânia Serra Neto Zúccari
Feb 23, 2020·Clinical and Experimental Reproductive Medicine·Maryam GholinezhadMilad Mohammadoo-Khorasani
Jul 10, 2019·Arab Journal of Urology·Sulagna DuttaAshok Agarwal
Nov 21, 2020·Andrologia·Yeganeh KoohestanidehaghiMahsaneh Vatankhah
Nov 4, 2020·Reproductive Sciences·Zahra BashiriMorteza Koruji
Jun 3, 2021·Clinical and Experimental Reproductive Medicine·Ahmed T AlahmarSulagna Dutta
Aug 8, 2021·Journal of Clinical Medicine·Paola ScaruffiPaola Anserini
Aug 14, 2021·Journal of Psychosomatic Obstetrics and Gynaecology·Samira Ebrahimzadeh ZagamiHelen T Allan
Nov 9, 2021·In Vitro Cellular & Developmental Biology. Animal·Marcela Bortoletto CerezettiFábio Morotti

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