Role of AQP2 during apoptosis in cortical collecting duct cells

Biology of the Cell
Pilar FlamencoC Capurro

Abstract

A major hallmark of apoptosis is cell shrinkage, termed apoptotic volume decrease, due to the cellular outflow of potassium and chloride ions, followed by osmotically obliged water. In many cells, the ionic pathways triggered during the apoptotic volume decrease may be similar to that observed during a regulatory volume decrease response under hypotonic conditions. However, the pathways involved in water loss during apoptosis have been largely ignored. It was recently reported that in some systems this water movement is mediated via specific water channels (aquaporins). Nevertheless, it is important to identify whether this is a ubiquitous aspect of apoptosis as well as to define the mechanisms involved. The aim of the present work was to investigate the role of aquaporin-2 during apoptosis in renal-collecting duct cells. We evaluated the putative relationship between aquaporin-2 expression and the activation of the ionic pathways involved in the regulatory volume response. Apoptosis was induced by incubating cells with a hypertonic solution or with cycloheximide in two cortical collecting duct cell lines: one not expressing aquaporins and the other stably transfected with aquaporin-2. Typical features of apoptosis were evaluat...Continue Reading

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Citations

Jan 23, 2016·The International Journal of Biochemistry & Cell Biology·Haifeng ZhangLixin Chen
Jan 12, 2016·Channels·Ana Galán-CoboMiriam Echevarría
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Oct 20, 2019·Journal of Cellular Physiology·Gisela Di GiustoClaudia Capurro
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May 31, 2019·Cellular and Molecular Life Sciences : CMLS·Paolo Armando Gagliardi, Luca Primo
Nov 17, 2020·Frontiers in Cell and Developmental Biology·Priyanka S Rana, Michael A Model

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Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis