Role of aquaporins in oral cancer

Journal of Cancer Research and Therapeutics
Mamatha G S Reddy, Elizabeth Dony

Abstract

Aquaporins (AQP) are the membrane proteins involved in the transport of water and some neutral solutes. Thirteen types of AQP are identified in various human tissues. The expression of AQP's has been studied in various tumors among one is oral cancer. These molecules are involved in cell proliferation, migration, and metastasis. AQP target inhibitors act directly or indirectly through focal adhesion kinase-mitogen-activated protein kinase signaling pathway and shown promising results along with anti-cancer drugs. However, further researches were required to verify the efficiency and safety of these AQPs-target inhibitors in clinical therapy.

Citations

Feb 23, 2020·International Journal of Molecular Sciences·Mérin Barbara StamboniCláudia Malheiros Coutinho-Camillo
Nov 15, 2020·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·M S LekshmyA Reshmi

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