Role of area postrema in transgene hypertension

Hypertension
D B AverillC M Ferrario

Abstract

Transgenic [Tg(+)] rats carrying the mouse Ren-2d gene [(mRen-2d)27] are a newly established monogenetic form of experimental hypertension. To determine whether the area postrema contributes to the development of hypertension in mRen-2 Tg(+) rats, this circumventricular organ in the fourth ventricle was removed from 5-week-old Tg(+) rats. From weeks 4 through 9, systolic blood pressure was measured weekly by tail-cuff plethysmography in area postrema-lesioned and sham-lesioned Tg(+) rats. Although systolic blood pressure rose markedly in sham-lesioned Tg(+) rats, the increase in systolic blood pressure was significantly attenuated in area postrema-lesioned Tg(+) rats. At 9 weeks of age, a femoral artery was cannulated for the measurement of arterial pressure in awake rats. Mean arterial pressure (MAP) in area postrema-lesioned Tg(+) rats was significantly (P < .01) lower than that in sham-lesioned rats: 171 +/- 7 and 132.+/- 5 mm Hg, respectively. Baroreceptor reflex was evaluated by intravenous infusion of sodium nitroprusside. There was no significant difference in baroreceptor reflex sensitivity between the two groups. Intravenous pentolinium (5 mg/kg), used to produce sympathetic ganglionic block, caused significant decreas...Continue Reading

References

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Citations

May 17, 2001·Current Hypertension Reports·J M Wyss, S H Carlson
Mar 8, 2005·Current Hypertension Reports·Annabelle Reaux-Le GoazigoCatherine Llorens-Cortes
Sep 12, 2000·Current Hypertension Reports·J M Wyss, S H Carlson
Apr 28, 2000·Journal of the Autonomic Nervous System·J F Paton, S Kasparov
Apr 11, 2001·Trends in Endocrinology and Metabolism : TEM·A ReauxC Llorens-Cortes
Jun 1, 2000·Clinical and Experimental Pharmacology & Physiology·V S Bishop, M G Sanderford
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·A ReauxC Llorens-Cortes
May 12, 2004·Proceedings of the National Academy of Sciences of the United States of America·Marie-Claude Fournie-ZaluskiCatherine Llorens-Cortes
Mar 1, 1996·Hypertension·M F CallahanM Morris
Jan 16, 2008·Journal of Neuroendocrinology·C Llorens-Cortes, C Kordon
Jul 17, 1999·The American Journal of Physiology·J L LiuI H Zucker
Apr 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Max G Sanderford, Vernon S Bishop
Aug 12, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Robin L Davisson
Oct 9, 2021·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Lenka ŘezáčováJosef Zicha

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